Controversies in preterm brain injury

Anna A. Penn, Pierre Gressens, Bobbi Fleiss, Stephen A. Back, Vittorio Gallo

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


In this review, we highlight critical unresolved questions in the etiology and mechanisms causing preterm brain injury. Involvement of neurons, glia, endogenous factors and exogenous exposures is considered. The structural and functional correlates of interrupted development and injury in the premature brain are under active investigation, with the hope that the cellular and molecular mechanisms underlying developmental abnormalities in the human preterm brain can be understood, prevented or repaired.

Original languageEnglish (US)
Pages (from-to)90-101
Number of pages12
JournalNeurobiology of Disease
Issue numberPart A
StatePublished - 2016


  • Brain development
  • Neuroimaging
  • Preterm brain injury
  • White matter injury

ASJC Scopus subject areas

  • Neurology


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