Contribution of fimbrial operons to attachment to and invasion of epithelial cell lines by Salmonella typhimurium

Andreas J. Bäumler, Renée M. Tsolis, Fred Heffron

    Research output: Contribution to journalArticle

    110 Scopus citations

    Abstract

    The role of the Salmonella typhimurium fimbrial operons, lpf, fim, and pef, in adhesion to and invasion of epithelial cell lines was investigated. An S. typhimurium lpfC mutant was unable to adhere to or to invade HEp-2 cells, while an S. typhimurium fim deletion mutant did not attach to or enter HeLa cells. These results suggest that adhesion is a prerequisite for invasion and that distinct fimbrial adhesins select different target cells for invasion by S. typhimurium.

    Original languageEnglish (US)
    Pages (from-to)1862-1865
    Number of pages4
    JournalInfection and Immunity
    Volume64
    Issue number5
    DOIs
    StatePublished - 1996

    ASJC Scopus subject areas

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases

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