TY - JOUR
T1 - Contribution of fimbrial operons to attachment to and invasion of epithelial cell lines by Salmonella typhimurium
AU - Bäumler, Andreas J.
AU - Tsolis, Renée M.
AU - Heffron, Fred
PY - 1996
Y1 - 1996
N2 - The role of the Salmonella typhimurium fimbrial operons, lpf, fim, and pef, in adhesion to and invasion of epithelial cell lines was investigated. An S. typhimurium lpfC mutant was unable to adhere to or to invade HEp-2 cells, while an S. typhimurium fim deletion mutant did not attach to or enter HeLa cells. These results suggest that adhesion is a prerequisite for invasion and that distinct fimbrial adhesins select different target cells for invasion by S. typhimurium.
AB - The role of the Salmonella typhimurium fimbrial operons, lpf, fim, and pef, in adhesion to and invasion of epithelial cell lines was investigated. An S. typhimurium lpfC mutant was unable to adhere to or to invade HEp-2 cells, while an S. typhimurium fim deletion mutant did not attach to or enter HeLa cells. These results suggest that adhesion is a prerequisite for invasion and that distinct fimbrial adhesins select different target cells for invasion by S. typhimurium.
UR - http://www.scopus.com/inward/record.url?scp=0029922244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029922244&partnerID=8YFLogxK
U2 - 10.1128/iai.64.5.1862-1865.1996
DO - 10.1128/iai.64.5.1862-1865.1996
M3 - Article
C2 - 8613405
AN - SCOPUS:0029922244
SN - 0019-9567
VL - 64
SP - 1862
EP - 1865
JO - Infection and Immunity
JF - Infection and Immunity
IS - 5
ER -