Contralateral effect of topical β-adrenergic antagonists in initial one-eyed trials in the Ocular Hypertension Treatment Study

Jody Piltz, Ronald Gross, Dong H. Shin, Julia A. Beiser, David Dorr, Michael A. Kass, Mae O. Gordon

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To evaluate the magnitude of the contralateral effect of topically administered β-blockers on intraocular pressure. METHODS: The Ocular Hypertension Treatment Study enrolled 1,636 subjects. Of these, 817 subjects were randomized to receive topical ocular hypotensive medication and 819 subjects were randomized to close observation (i.e., no topical medication). We compared the intraocular pressure of the contralateral eye of subjects at the baseline visit and after an initial one-eyed therapeutic trial of topical β-blockers. We examined differences between baseline and follow-up intraocular pressure in untreated eyes of subjects randomized to close observation. RESULTS: The mean reduction in intraocular pressure in the β-blocker-treated eyes was -5.9 ± 3.4 mm Hg (-22% ± 12%; Student t test, P <.0001). In the contralateral eyes, mean intraocular pressure reduction was -1.5 ± 3.0 mm Hg (-5.8% ± 12%; P

Original languageEnglish (US)
Pages (from-to)441-453
Number of pages13
JournalAmerican Journal of Ophthalmology
Volume130
Issue number4
DOIs
StatePublished - Oct 2000
Externally publishedYes

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Ocular Hypertension
Adrenergic Antagonists
Intraocular Pressure
Observation
Therapeutics
Students

ASJC Scopus subject areas

  • Ophthalmology

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Contralateral effect of topical β-adrenergic antagonists in initial one-eyed trials in the Ocular Hypertension Treatment Study. / Piltz, Jody; Gross, Ronald; Shin, Dong H.; Beiser, Julia A.; Dorr, David; Kass, Michael A.; Gordon, Mae O.

In: American Journal of Ophthalmology, Vol. 130, No. 4, 10.2000, p. 441-453.

Research output: Contribution to journalArticle

Piltz, Jody ; Gross, Ronald ; Shin, Dong H. ; Beiser, Julia A. ; Dorr, David ; Kass, Michael A. ; Gordon, Mae O. / Contralateral effect of topical β-adrenergic antagonists in initial one-eyed trials in the Ocular Hypertension Treatment Study. In: American Journal of Ophthalmology. 2000 ; Vol. 130, No. 4. pp. 441-453.
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