Continuous dopaminergic stimulation: Is it the answer to the motor complications of levodopa?

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87 Scopus citations

Abstract

Continuous dopaminergic stimulation (CDS) is a treatment strategy hypothesized to avoid or reduce the motor complications of long-term levodopa therapy, motor fluctuations, and dyskinesia, by preventing or reversing sensitization induced by pulsatile dopaminergic stimulation. The CDS hypothesis is itself based on several hypotheses. First, tonic dopaminergic stimulation is physiological. Second, sensitization is undesirable and should be reversed. Third, reduction of off time and dyskinesia can be induced simultaneously. Finally, clinical studies substantiate the CDS hypothesis. The evidence for these hypotheses is reviewed, and the need for randomized clinical trials that rigorously test the CDS hypothesis is emphasized.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalMovement Disorders
Volume22
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Continuous dopaminergic stimulation
  • Levodopa
  • Randomized clinical trials
  • Sensitization
  • Tolerance

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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