Congenital virilization of female infants recognized after pregnancies with retained levonorgestrel intrauterine devices

Helen Y. Hougen, Casey A. Seideman, Margaret P. Adam, Anne Marie Amies Oelschlager, Patricia Y. Fechner, Linda Ramsell, Margarett Shnorhavorian, Audrey Squire, J. Christopher Austin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The Mirena intrauterine device (IUD) is a hormone-secreting contraceptive device. Pregnancy with the Mirena is rare and effects to the fetus are unknown. Here we present four females with genital virilization after pregnancy with persistent Mirena IUD. All patients had a 46, XX karyotype and normal hormone evaluation. All underwent exam under anesthesia, demonstrating posterior labial fusion and short urogenital sinus with normal bladder, urethra, vagina, and cervix. Three of four patients underwent flap vaginoplasty without complications and good cosmetic outcomes. This series suggests that persistent levonorgestrel-secreting IUD during pregnancy is associated with genital virilization in female fetuses.

Original languageEnglish (US)
Pages (from-to)241-243
Number of pages3
JournalJournal of Pediatric Urology
Volume16
Issue number2
DOIs
StatePublished - Apr 2020

Keywords

  • Ambiguous genitalia
  • Genital virilization
  • Levonorgestrel
  • Urogenital sinus
  • Vaginoplasty

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Urology

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