Congenital virilization of female infants recognized after pregnancies with retained levonorgestrel intrauterine devices

Helen Y. Hougen; Casey A. Seideman; Margaret P. Adam; Anne Marie Amies Oelschlager; Patricia Y. Fechner; Linda Ramsell; Margarett Shnorhavorian; Audrey Squire; J. Christopher Austin

doi:10.1016/j.jpurol.2020.03.008

Congenital virilization of female infants recognized after pregnancies with retained levonorgestrel intrauterine devices

Helen Y. Hougen, Casey A. Seideman, Margaret P. Adam, Anne Marie Amies Oelschlager, Patricia Y. Fechner, Linda Ramsell, Margarett Shnorhavorian, Audrey Squire, J. Christopher Austin

Urology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The Mirena intrauterine device (IUD) is a hormone-secreting contraceptive device. Pregnancy with the Mirena is rare and effects to the fetus are unknown. Here we present four females with genital virilization after pregnancy with persistent Mirena IUD. All patients had a 46, XX karyotype and normal hormone evaluation. All underwent exam under anesthesia, demonstrating posterior labial fusion and short urogenital sinus with normal bladder, urethra, vagina, and cervix. Three of four patients underwent flap vaginoplasty without complications and good cosmetic outcomes. This series suggests that persistent levonorgestrel-secreting IUD during pregnancy is associated with genital virilization in female fetuses.

Original language	English (US)
Pages (from-to)	241-243
Number of pages	3
Journal	Journal of Pediatric Urology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.jpurol.2020.03.008
State	Published - Apr 2020

Keywords

Ambiguous genitalia
Genital virilization
Levonorgestrel
Urogenital sinus
Vaginoplasty

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Urology

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10.1016/j.jpurol.2020.03.008

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title = "Congenital virilization of female infants recognized after pregnancies with retained levonorgestrel intrauterine devices",

abstract = "The Mirena intrauterine device (IUD) is a hormone-secreting contraceptive device. Pregnancy with the Mirena is rare and effects to the fetus are unknown. Here we present four females with genital virilization after pregnancy with persistent Mirena IUD. All patients had a 46, XX karyotype and normal hormone evaluation. All underwent exam under anesthesia, demonstrating posterior labial fusion and short urogenital sinus with normal bladder, urethra, vagina, and cervix. Three of four patients underwent flap vaginoplasty without complications and good cosmetic outcomes. This series suggests that persistent levonorgestrel-secreting IUD during pregnancy is associated with genital virilization in female fetuses.",

keywords = "Ambiguous genitalia, Genital virilization, Levonorgestrel, Urogenital sinus, Vaginoplasty",

author = "Hougen, {Helen Y.} and Seideman, {Casey A.} and Adam, {Margaret P.} and {Amies Oelschlager}, {Anne Marie} and Fechner, {Patricia Y.} and Linda Ramsell and Margarett Shnorhavorian and Audrey Squire and Austin, {J. Christopher}",

note = "Publisher Copyright: {\textcopyright} 2020 Journal of Pediatric Urology Company",

year = "2020",

month = apr,

doi = "10.1016/j.jpurol.2020.03.008",

language = "English (US)",

volume = "16",

pages = "241--243",

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T1 - Congenital virilization of female infants recognized after pregnancies with retained levonorgestrel intrauterine devices

AU - Hougen, Helen Y.

AU - Seideman, Casey A.

AU - Adam, Margaret P.

AU - Amies Oelschlager, Anne Marie

AU - Fechner, Patricia Y.

AU - Ramsell, Linda

AU - Shnorhavorian, Margarett

AU - Squire, Audrey

AU - Austin, J. Christopher

PY - 2020/4

Y1 - 2020/4

N2 - The Mirena intrauterine device (IUD) is a hormone-secreting contraceptive device. Pregnancy with the Mirena is rare and effects to the fetus are unknown. Here we present four females with genital virilization after pregnancy with persistent Mirena IUD. All patients had a 46, XX karyotype and normal hormone evaluation. All underwent exam under anesthesia, demonstrating posterior labial fusion and short urogenital sinus with normal bladder, urethra, vagina, and cervix. Three of four patients underwent flap vaginoplasty without complications and good cosmetic outcomes. This series suggests that persistent levonorgestrel-secreting IUD during pregnancy is associated with genital virilization in female fetuses.

AB - The Mirena intrauterine device (IUD) is a hormone-secreting contraceptive device. Pregnancy with the Mirena is rare and effects to the fetus are unknown. Here we present four females with genital virilization after pregnancy with persistent Mirena IUD. All patients had a 46, XX karyotype and normal hormone evaluation. All underwent exam under anesthesia, demonstrating posterior labial fusion and short urogenital sinus with normal bladder, urethra, vagina, and cervix. Three of four patients underwent flap vaginoplasty without complications and good cosmetic outcomes. This series suggests that persistent levonorgestrel-secreting IUD during pregnancy is associated with genital virilization in female fetuses.

KW - Ambiguous genitalia

KW - Genital virilization

KW - Levonorgestrel

KW - Urogenital sinus

KW - Vaginoplasty

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ER -

Congenital virilization of female infants recognized after pregnancies with retained levonorgestrel intrauterine devices

Abstract

Keywords

ASJC Scopus subject areas

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