Congenic Mapping of Alcohol and Pentobarbital Withdrawal Liability Loci to a

Christoph Fehr, Renee L. Shirley, John Belknap, John Jr Crabbe, Kari Buck

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Risk for onset of alcoholism is related to genetic differences in acute alcohol withdrawal liability. We previously mapped a locus responsible for 26% of the genetic variance in acute alcohol withdrawal convulsion liability to a >35 centimorgan (cM) interval of murine chromosome 4. Here, we narrow the position of this locus to a

Original languageEnglish (US)
Pages (from-to)3730-3738
Number of pages9
JournalJournal of Neuroscience
Volume22
Issue number9
StatePublished - May 1 2002

Fingerprint

Pentobarbital
Alcohols
Chromosomes, Human, Pair 4
Alcoholism
Seizures

Keywords

  • Barbiturate
  • C57BL/6J
  • Convulsion
  • DBA/2J
  • Ethanol
  • Interval-specific congenic strain
  • PDZ domain
  • Physiological dependence
  • Quantitative trait locus
  • Recombinant progeny testing
  • Seizure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Congenic Mapping of Alcohol and Pentobarbital Withdrawal Liability Loci to a . / Fehr, Christoph; Shirley, Renee L.; Belknap, John; Crabbe, John Jr; Buck, Kari.

In: Journal of Neuroscience, Vol. 22, No. 9, 01.05.2002, p. 3730-3738.

Research output: Contribution to journalArticle

Fehr, Christoph ; Shirley, Renee L. ; Belknap, John ; Crabbe, John Jr ; Buck, Kari. / Congenic Mapping of Alcohol and Pentobarbital Withdrawal Liability Loci to a . In: Journal of Neuroscience. 2002 ; Vol. 22, No. 9. pp. 3730-3738.
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