Abstract
Disease course in people with multiple sclerosis (MS) is heterogeneous. The impact of dietary and nutritional factors on MS prognosis is of interest to both patients and clinicians; differences in diet are hypothesized to contribute to disease evolution over time. However, studying diet, especially in people with MS, introduces methodologic complexity that should be recognized. In this review, we focus on methodological aspects relevant to the conduct of dietary interventions in people with MS, given our experience in leading such studies and the challenges we encountered in the realization of this work. We summarize key aspects of study design and important considerations, regardless of the specifics of the actual study (e.g. the particular diet of interest, target MS population, etc.). We discuss strategies for the design of the intervention as well as the selection of appropriate study endpoints. Finally, we provide an overview of strategies to improve the rigor of conducting dietary studies in people with MS.
| Original language | English (US) |
|---|---|
| Article number | 101478 |
| Journal | Multiple sclerosis and related disorders |
| Volume | 37 |
| DOIs | |
| State | Published - Jan 2020 |
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Keywords
- Diet
- Diet intervention
- Multiple sclerosis
- Study design
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Conducting dietary intervention trials in people with multiple sclerosis : Lessons learned and a path forward. / Fitzgerald, Kathryn C.; Sand, Ilana Katz; Senders, Angela; Spain, Rebecca; Giesser, Barbara; Sullivan, Patrick; Baer, David J.; LaRocca, Nicholas; Zackowski, Kathleen; Mowry, Ellen M.
In: Multiple sclerosis and related disorders, Vol. 37, 101478, 01.2020.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Conducting dietary intervention trials in people with multiple sclerosis
T2 - Lessons learned and a path forward
AU - Fitzgerald, Kathryn C.
AU - Sand, Ilana Katz
AU - Senders, Angela
AU - Spain, Rebecca
AU - Giesser, Barbara
AU - Sullivan, Patrick
AU - Baer, David J.
AU - LaRocca, Nicholas
AU - Zackowski, Kathleen
AU - Mowry, Ellen M.
PY - 2020/1
Y1 - 2020/1
N2 - Disease course in people with multiple sclerosis (MS) is heterogeneous. The impact of dietary and nutritional factors on MS prognosis is of interest to both patients and clinicians; differences in diet are hypothesized to contribute to disease evolution over time. However, studying diet, especially in people with MS, introduces methodologic complexity that should be recognized. In this review, we focus on methodological aspects relevant to the conduct of dietary interventions in people with MS, given our experience in leading such studies and the challenges we encountered in the realization of this work. We summarize key aspects of study design and important considerations, regardless of the specifics of the actual study (e.g. the particular diet of interest, target MS population, etc.). We discuss strategies for the design of the intervention as well as the selection of appropriate study endpoints. Finally, we provide an overview of strategies to improve the rigor of conducting dietary studies in people with MS.
AB - Disease course in people with multiple sclerosis (MS) is heterogeneous. The impact of dietary and nutritional factors on MS prognosis is of interest to both patients and clinicians; differences in diet are hypothesized to contribute to disease evolution over time. However, studying diet, especially in people with MS, introduces methodologic complexity that should be recognized. In this review, we focus on methodological aspects relevant to the conduct of dietary interventions in people with MS, given our experience in leading such studies and the challenges we encountered in the realization of this work. We summarize key aspects of study design and important considerations, regardless of the specifics of the actual study (e.g. the particular diet of interest, target MS population, etc.). We discuss strategies for the design of the intervention as well as the selection of appropriate study endpoints. Finally, we provide an overview of strategies to improve the rigor of conducting dietary studies in people with MS.
KW - Diet
KW - Diet intervention
KW - Multiple sclerosis
KW - Study design
UR - http://www.scopus.com/inward/record.url?scp=85074455766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074455766&partnerID=8YFLogxK
U2 - 10.1016/j.msard.2019.101478
DO - 10.1016/j.msard.2019.101478
M3 - Review article
C2 - 31704546
AN - SCOPUS:85074455766
VL - 37
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
SN - 2211-0348
M1 - 101478
ER -