Conditioned release of neurotransmitters as measured by microdialysis.

B. G. Hoebel, Gregory Mark, H. L. West

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The purpose of this research was to measure conditioned release of neurotransmitters in vivo and to study their role as neuromodulators in neural circuits controlling food intake. 1. Extracellular serotonin (5HT) was measured in the hypothalamus during (a) injection of the anorectic drug d-fenfluramine, (b) a normal meal and (c) during the taste of a flavor that previously had been paired with nausea. All these situations increased 5HT, suggesting it plays a role in suppression of food intake. 2. Extracellular dopamine (DA) in the nucleus accumbens (NAC) was released (a) during eating and (b) by a conditioned taste associated with intragastric infusion of carbohydrate, but (c) DA decreased in response to a taste that had been paired with nausea. Thus some DA projections to the NAC may modulate circuits that reinforce eating safe food. Drugs that release DA mimic, in part, this safe food effect.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
JournalClinical Neuropharmacology
Volume15 Suppl 1 Pt A
StatePublished - 1992
Externally publishedYes

Fingerprint

Microdialysis
Neurotransmitter Agents
Dopamine
Eating
Nucleus Accumbens
Nausea
Fenfluramine
Food
Appetite Depressants
Hypothalamus
Meals
Serotonin
Carbohydrates
Injections
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Hoebel, B. G., Mark, G., & West, H. L. (1992). Conditioned release of neurotransmitters as measured by microdialysis. Clinical Neuropharmacology, 15 Suppl 1 Pt A.

Conditioned release of neurotransmitters as measured by microdialysis. / Hoebel, B. G.; Mark, Gregory; West, H. L.

In: Clinical Neuropharmacology, Vol. 15 Suppl 1 Pt A, 1992.

Research output: Contribution to journalArticle

Hoebel, BG, Mark, G & West, HL 1992, 'Conditioned release of neurotransmitters as measured by microdialysis.', Clinical Neuropharmacology, vol. 15 Suppl 1 Pt A.
Hoebel, B. G. ; Mark, Gregory ; West, H. L. / Conditioned release of neurotransmitters as measured by microdialysis. In: Clinical Neuropharmacology. 1992 ; Vol. 15 Suppl 1 Pt A.
@article{acef6c86f1014d5bb0519cd9efe58676,
title = "Conditioned release of neurotransmitters as measured by microdialysis.",
abstract = "The purpose of this research was to measure conditioned release of neurotransmitters in vivo and to study their role as neuromodulators in neural circuits controlling food intake. 1. Extracellular serotonin (5HT) was measured in the hypothalamus during (a) injection of the anorectic drug d-fenfluramine, (b) a normal meal and (c) during the taste of a flavor that previously had been paired with nausea. All these situations increased 5HT, suggesting it plays a role in suppression of food intake. 2. Extracellular dopamine (DA) in the nucleus accumbens (NAC) was released (a) during eating and (b) by a conditioned taste associated with intragastric infusion of carbohydrate, but (c) DA decreased in response to a taste that had been paired with nausea. Thus some DA projections to the NAC may modulate circuits that reinforce eating safe food. Drugs that release DA mimic, in part, this safe food effect.(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "Hoebel, {B. G.} and Gregory Mark and West, {H. L.}",
year = "1992",
language = "English (US)",
volume = "15 Suppl 1 Pt A",
journal = "Clinical Neuropharmacology",
issn = "0362-5664",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Conditioned release of neurotransmitters as measured by microdialysis.

AU - Hoebel, B. G.

AU - Mark, Gregory

AU - West, H. L.

PY - 1992

Y1 - 1992

N2 - The purpose of this research was to measure conditioned release of neurotransmitters in vivo and to study their role as neuromodulators in neural circuits controlling food intake. 1. Extracellular serotonin (5HT) was measured in the hypothalamus during (a) injection of the anorectic drug d-fenfluramine, (b) a normal meal and (c) during the taste of a flavor that previously had been paired with nausea. All these situations increased 5HT, suggesting it plays a role in suppression of food intake. 2. Extracellular dopamine (DA) in the nucleus accumbens (NAC) was released (a) during eating and (b) by a conditioned taste associated with intragastric infusion of carbohydrate, but (c) DA decreased in response to a taste that had been paired with nausea. Thus some DA projections to the NAC may modulate circuits that reinforce eating safe food. Drugs that release DA mimic, in part, this safe food effect.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - The purpose of this research was to measure conditioned release of neurotransmitters in vivo and to study their role as neuromodulators in neural circuits controlling food intake. 1. Extracellular serotonin (5HT) was measured in the hypothalamus during (a) injection of the anorectic drug d-fenfluramine, (b) a normal meal and (c) during the taste of a flavor that previously had been paired with nausea. All these situations increased 5HT, suggesting it plays a role in suppression of food intake. 2. Extracellular dopamine (DA) in the nucleus accumbens (NAC) was released (a) during eating and (b) by a conditioned taste associated with intragastric infusion of carbohydrate, but (c) DA decreased in response to a taste that had been paired with nausea. Thus some DA projections to the NAC may modulate circuits that reinforce eating safe food. Drugs that release DA mimic, in part, this safe food effect.(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0026443328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026443328&partnerID=8YFLogxK

M3 - Article

C2 - 1354074

AN - SCOPUS:0026443328

VL - 15 Suppl 1 Pt A

JO - Clinical Neuropharmacology

JF - Clinical Neuropharmacology

SN - 0362-5664

ER -