Computed tomography and magnetic resonance imaging of adult renal cell carcinoma associated with Xp11.2 translocation

Trien T. Dang, Etay Ziv, Stefanie Weinstein, Maxwell V. Meng, Zhen Wang, Fergus V. Coakley

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Objective: This study aimed to report the computed tomography (CT) and magnetic resonance imaging (MRI) findings of renal cell carcinoma associated with Xp11.2 translocation in adults. Methods: We retrospectively identified 9 adults with renal cell carcinoma associated with Xp11.2 translocation who underwent baseline cross-sectional imaging with CT (n = 9) or MRI (n = 3). All available clinical, imaging, and histopathological records were reviewed. Results: Mean patient age was 24 years (range, 18-45 years). Eight of 9 cancers demonstrated imaging findings of hemorrhage or necrosis (n = 3), advanced stage disease (n = 2), or both (n = 3) at CT or MRI. Conclusions: The possibility of renal cell carcinoma associated with Xp11.2 translocation should be considered for a renal mass seen in a patient 45 years or younger, which demonstrates hemorrhage or necrosis or advanced stage disease at CT or MRI.

Original languageEnglish (US)
Pages (from-to)669-674
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume36
Issue number6
DOIs
StatePublished - Nov 1 2012

Keywords

  • CT
  • MRI
  • Renal cell carcinoma
  • TFE3 gene fusion carcinoma
  • Xp11.2 translocation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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