Abstract
An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.
Original language | English (US) |
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Pages (from-to) | 711-722 |
Number of pages | 12 |
Journal | Cancer Cell |
Volume | 29 |
Issue number | 5 |
DOIs | |
State | Published - May 9 2016 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research