Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients

Yuan Yuan, Lingxiang Liu, Hu Chen, Yumeng Wang, Yanxun Xu, Huzhang Mao, Jun Li, Gordon Mills, Yongqian Shu, Liang Li, Han Liang

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.

Original languageEnglish (US)
Pages (from-to)711-722
Number of pages12
JournalCancer Cell
Volume29
Issue number5
DOIs
StatePublished - May 9 2016
Externally publishedYes

Fingerprint

Neoplasms
Atlases
Incidence
Genes
Genome
Mortality
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients. / Yuan, Yuan; Liu, Lingxiang; Chen, Hu; Wang, Yumeng; Xu, Yanxun; Mao, Huzhang; Li, Jun; Mills, Gordon; Shu, Yongqian; Li, Liang; Liang, Han.

In: Cancer Cell, Vol. 29, No. 5, 09.05.2016, p. 711-722.

Research output: Contribution to journalArticle

Yuan, Y, Liu, L, Chen, H, Wang, Y, Xu, Y, Mao, H, Li, J, Mills, G, Shu, Y, Li, L & Liang, H 2016, 'Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients', Cancer Cell, vol. 29, no. 5, pp. 711-722. https://doi.org/10.1016/j.ccell.2016.04.001
Yuan, Yuan ; Liu, Lingxiang ; Chen, Hu ; Wang, Yumeng ; Xu, Yanxun ; Mao, Huzhang ; Li, Jun ; Mills, Gordon ; Shu, Yongqian ; Li, Liang ; Liang, Han. / Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients. In: Cancer Cell. 2016 ; Vol. 29, No. 5. pp. 711-722.
@article{822f71092e2b476cb1a71a3177f4af70,
title = "Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients",
abstract = "An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53{\%} of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.",
author = "Yuan Yuan and Lingxiang Liu and Hu Chen and Yumeng Wang and Yanxun Xu and Huzhang Mao and Jun Li and Gordon Mills and Yongqian Shu and Liang Li and Han Liang",
year = "2016",
month = "5",
day = "9",
doi = "10.1016/j.ccell.2016.04.001",
language = "English (US)",
volume = "29",
pages = "711--722",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients

AU - Yuan, Yuan

AU - Liu, Lingxiang

AU - Chen, Hu

AU - Wang, Yumeng

AU - Xu, Yanxun

AU - Mao, Huzhang

AU - Li, Jun

AU - Mills, Gordon

AU - Shu, Yongqian

AU - Li, Liang

AU - Liang, Han

PY - 2016/5/9

Y1 - 2016/5/9

N2 - An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.

AB - An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.

UR - http://www.scopus.com/inward/record.url?scp=84975263640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975263640&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2016.04.001

DO - 10.1016/j.ccell.2016.04.001

M3 - Article

C2 - 27165743

AN - SCOPUS:84975263640

VL - 29

SP - 711

EP - 722

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 5

ER -