Abstract
An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 711-722 |
| Number of pages | 12 |
| Journal | Cancer Cell |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 9 2016 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Oncology
- Cell Biology
- Cancer Research
Cite this
Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients. / Yuan, Yuan; Liu, Lingxiang; Chen, Hu; Wang, Yumeng; Xu, Yanxun; Mao, Huzhang; Li, Jun; Mills, Gordon; Shu, Yongqian; Li, Liang; Liang, Han.
In: Cancer Cell, Vol. 29, No. 5, 09.05.2016, p. 711-722.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients
AU - Yuan, Yuan
AU - Liu, Lingxiang
AU - Chen, Hu
AU - Wang, Yumeng
AU - Xu, Yanxun
AU - Mao, Huzhang
AU - Li, Jun
AU - Mills, Gordon
AU - Shu, Yongqian
AU - Li, Liang
AU - Liang, Han
PY - 2016/5/9
Y1 - 2016/5/9
N2 - An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.
AB - An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.
UR - http://www.scopus.com/inward/record.url?scp=84975263640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975263640&partnerID=8YFLogxK
U2 - 10.1016/j.ccell.2016.04.001
DO - 10.1016/j.ccell.2016.04.001
M3 - Article
C2 - 27165743
AN - SCOPUS:84975263640
VL - 29
SP - 711
EP - 722
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 5
ER -