Composite Mandibulectomy

A novel animal model

Douglas R. Sidell, Tara Aghaloo, Sotirios Tetradis, Min Lee, Olga Bezouglaia, Adam Deconde, Maie A. St. John

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives. Segmental mandibular defects can result after the treatment of various pathologic processes, including osteoradionecrosis, tumor resection, or fracture nonunion with sequestration. The variety of etiologies and the frequency of occurrence make the reconstruction of segmental mandibular defects a topic of significant interest. Despite these incentives, a well-established small-animal model of the segmental mandibulectomy, including composite resection, does not exist. The objective of this study is the creation of a reliable animal model that can be used to study the reconstruction of en bloc mandibular defects. Surgical techniques and an array of reconstructive options are described.Study design. Description of an animal model.Setting. Animal laboratory at a quaternary care university medical center.Methods. We present an Animal Research Oversight Committee-approved prospective analysis of survival operations in the rat model. A detailed, stepwise description of surgical technique and relevant intraoperative anatomy is presented. Postoperative management, early pitfalls, surgical complications, and future applications are discussed.Results. A total of 72 operations were performed by a single individual between July and October 2010. Two intraoperative and 9 postoperative complications were recognized. There were 6 orocutaneous fistulas, 2 abscesses, and 1 seroma. There were 4 fatalities, which were attributed to anesthetic complications (2, intraoperative), hematoma formation (1, postoperative), and foreign-body aspiration (1, postoperative).Conclusion. This novel animal model reliably replicates the en bloc segmental mandibular defects seen in our patient population and can be manipulated to achieve a wide variety of research objectives.

Original languageEnglish (US)
Pages (from-to)932-937
Number of pages6
JournalOtolaryngology - Head and Neck Surgery (United States)
Volume146
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Animal Models
Osteoradionecrosis
Mandibular Osteotomy
Mandibular Reconstruction
Seroma
Intraoperative Complications
Laboratory Animals
Pathologic Processes
Survival Analysis
Foreign Bodies
Hematoma
Abscess
Fistula
Anesthetics
Motivation
Anatomy
Research
Population
Neoplasms
Therapeutics

Keywords

  • biomaterials
  • composite
  • head and neck
  • mandible

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Sidell, D. R., Aghaloo, T., Tetradis, S., Lee, M., Bezouglaia, O., Deconde, A., & St. John, M. A. (2012). Composite Mandibulectomy: A novel animal model. Otolaryngology - Head and Neck Surgery (United States), 146(6), 932-937. https://doi.org/10.1177/0194599811435633

Composite Mandibulectomy : A novel animal model. / Sidell, Douglas R.; Aghaloo, Tara; Tetradis, Sotirios; Lee, Min; Bezouglaia, Olga; Deconde, Adam; St. John, Maie A.

In: Otolaryngology - Head and Neck Surgery (United States), Vol. 146, No. 6, 06.2012, p. 932-937.

Research output: Contribution to journalArticle

Sidell, DR, Aghaloo, T, Tetradis, S, Lee, M, Bezouglaia, O, Deconde, A & St. John, MA 2012, 'Composite Mandibulectomy: A novel animal model', Otolaryngology - Head and Neck Surgery (United States), vol. 146, no. 6, pp. 932-937. https://doi.org/10.1177/0194599811435633
Sidell DR, Aghaloo T, Tetradis S, Lee M, Bezouglaia O, Deconde A et al. Composite Mandibulectomy: A novel animal model. Otolaryngology - Head and Neck Surgery (United States). 2012 Jun;146(6):932-937. https://doi.org/10.1177/0194599811435633
Sidell, Douglas R. ; Aghaloo, Tara ; Tetradis, Sotirios ; Lee, Min ; Bezouglaia, Olga ; Deconde, Adam ; St. John, Maie A. / Composite Mandibulectomy : A novel animal model. In: Otolaryngology - Head and Neck Surgery (United States). 2012 ; Vol. 146, No. 6. pp. 932-937.
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