Complex translocation (7;22) identified in an epithelioid hemangioendothelioma

Alan C. Boudousquie, Helen J. Lawce, Richard Sherman, Susan Olson, R. Ellen Magenis, Christopher L. Corless

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

We describe a malignant epithelioid hemangioendothelioma arising in the back of a 45-year-old man with pulmonary and bone marrow metastases. Light microscopic and immunohistochemical features of this tumor are presented. Karyotyping revealed several clonal abnormalities: a complex unbalanced translocation (7;22) involving multiple breakpoints (confirmed by fluorescence in situ hybridization), a Robertsonian t(14;14), and loss of the Y chromosome. Monosomy for chromosome 11 was noted in a subset of the tumor cells. To our knowledge a karyotype has not been previously reported for this unusual vascular tumor.

Original languageEnglish (US)
Pages (from-to)116-121
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume92
Issue number2
DOIs
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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