TY - JOUR
T1 - Complex translocation (7;22) identified in an epithelioid hemangioendothelioma
AU - Boudousquie, Alan C.
AU - Lawce, Helen J.
AU - Sherman, Richard
AU - Olson, Susan
AU - Magenis, R. Ellen
AU - Corless, Christopher L.
PY - 1996/12
Y1 - 1996/12
N2 - We describe a malignant epithelioid hemangioendothelioma arising in the back of a 45-year-old man with pulmonary and bone marrow metastases. Light microscopic and immunohistochemical features of this tumor are presented. Karyotyping revealed several clonal abnormalities: a complex unbalanced translocation (7;22) involving multiple breakpoints (confirmed by fluorescence in situ hybridization), a Robertsonian t(14;14), and loss of the Y chromosome. Monosomy for chromosome 11 was noted in a subset of the tumor cells. To our knowledge a karyotype has not been previously reported for this unusual vascular tumor.
AB - We describe a malignant epithelioid hemangioendothelioma arising in the back of a 45-year-old man with pulmonary and bone marrow metastases. Light microscopic and immunohistochemical features of this tumor are presented. Karyotyping revealed several clonal abnormalities: a complex unbalanced translocation (7;22) involving multiple breakpoints (confirmed by fluorescence in situ hybridization), a Robertsonian t(14;14), and loss of the Y chromosome. Monosomy for chromosome 11 was noted in a subset of the tumor cells. To our knowledge a karyotype has not been previously reported for this unusual vascular tumor.
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U2 - 10.1016/S0165-4608(96)00175-6
DO - 10.1016/S0165-4608(96)00175-6
M3 - Article
C2 - 8976367
AN - SCOPUS:0030465551
SN - 0165-4608
VL - 92
SP - 116
EP - 121
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -