Comparison of radiolabeled bleomycins and Gallium citrate in tumor bearing mice

Kenneth Krohn, J. M. Meyers, G. L. DeNardo, S. J. DeNardo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Radioiodinated bleomycin is a chemically stable radiopharmaceutical that can be prepared with high activity using 123I. Its pharmacokinetics were compared with those of 99mTc, 111In , and 57Co bleomycin, and 67Ga citrate in mice bearing a transplanted KHJJ tumor. The in vivo kinetics and stability of 123I and 57Co bleomycin were similar: both were acceptable, although not equivalent, tags for bleomycin and, along with 67Ga citrate, both had biologic properties suitable for tumor detection. Both 99Tc(m) and 111In bleomycin dissociated rapidly in vivo and hence do not represent legitimate tags for bleomycin. However, 111In bleomycin may have tumor localizing properties related to its biochemical properties after the indium and chelate separate in vivo. Iodine 123 is superior to either 57Co or 55Co. Tumor to blood and tumor to liver ratios were higher for I bleomycin than for 67Ga or Co bleomycin. The nearly ideal nuclear properties of 123I should complement the biologic properties of bleomycin and lead to a useful tumor radiodiagnostic agent.

Original languageEnglish (US)
Pages (from-to)276-281
Number of pages6
JournalJournal of Nuclear Medicine
Volume18
Issue number3
StatePublished - 1977
Externally publishedYes

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Bleomycin
Neoplasms
Citric Acid
gallium citrate
Indium
Radiopharmaceuticals
Iodine
Pharmacokinetics
Liver

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Krohn, K., Meyers, J. M., DeNardo, G. L., & DeNardo, S. J. (1977). Comparison of radiolabeled bleomycins and Gallium citrate in tumor bearing mice. Journal of Nuclear Medicine, 18(3), 276-281.

Comparison of radiolabeled bleomycins and Gallium citrate in tumor bearing mice. / Krohn, Kenneth; Meyers, J. M.; DeNardo, G. L.; DeNardo, S. J.

In: Journal of Nuclear Medicine, Vol. 18, No. 3, 1977, p. 276-281.

Research output: Contribution to journalArticle

Krohn, K, Meyers, JM, DeNardo, GL & DeNardo, SJ 1977, 'Comparison of radiolabeled bleomycins and Gallium citrate in tumor bearing mice', Journal of Nuclear Medicine, vol. 18, no. 3, pp. 276-281.
Krohn, Kenneth ; Meyers, J. M. ; DeNardo, G. L. ; DeNardo, S. J. / Comparison of radiolabeled bleomycins and Gallium citrate in tumor bearing mice. In: Journal of Nuclear Medicine. 1977 ; Vol. 18, No. 3. pp. 276-281.
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