Comparison of pharmacological and antimicrobial properties of cefadroxil and cephalexin

A. I. Hartstein, K. E. Patrick, S. R. Jones, M. J. Miller, Richard Bryant

Research output: Contribution to journalArticle

Abstract

Pharmacological and antimicrobial properties of cefadroxil, a new cephalosporin antibiotic, were compared with cephalexin. Absorption and excretion were studied in 20 healthy men. Peak concentrations of the drugs in serum were similar after ingestion of single 500 mg tablets. The concentration of cefadroxil in serum was more sustained than that of cephalexin. Levels of cefadroxil in serum after a dose of 1000 mg were approximately twice those after a 500 mg dose through 6 h. Each drug administered in a dose of 500 mg every 6 h for 24 h resulted in concentrations in serum that were similar to a single dose without accumulation. Ninety-three percent of the cefadroxil and 85% of the cephalexin were excreted in urine after ingestions of single 500 mg tablets. The urine concentration of cefadroxil was more sustained than cephalexin. Minimal inhibitory and minimal bactericidal concentrations for clinical isolates were comparable with each drug. Cefadroxil compares favorably with cephalexin in this study. Sustained levels of cefadroxil in serum and urine suggest that this drug may be given at less frequent intervals than cephalexin.

Original languageEnglish (US)
JournalInfection
Volume8
Issue number5 Supplement
DOIs
StatePublished - Sep 1980

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Cefadroxil
Cephalexin
Pharmacology
Serum
Urine
Pharmaceutical Preparations
Tablets
Eating
Cephalosporins

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Cite this

Hartstein, A. I., Patrick, K. E., Jones, S. R., Miller, M. J., & Bryant, R. (1980). Comparison of pharmacological and antimicrobial properties of cefadroxil and cephalexin. Infection, 8(5 Supplement). https://doi.org/10.1007/BF01639676

Comparison of pharmacological and antimicrobial properties of cefadroxil and cephalexin. / Hartstein, A. I.; Patrick, K. E.; Jones, S. R.; Miller, M. J.; Bryant, Richard.

In: Infection, Vol. 8, No. 5 Supplement, 09.1980.

Research output: Contribution to journalArticle

Hartstein, AI, Patrick, KE, Jones, SR, Miller, MJ & Bryant, R 1980, 'Comparison of pharmacological and antimicrobial properties of cefadroxil and cephalexin', Infection, vol. 8, no. 5 Supplement. https://doi.org/10.1007/BF01639676
Hartstein AI, Patrick KE, Jones SR, Miller MJ, Bryant R. Comparison of pharmacological and antimicrobial properties of cefadroxil and cephalexin. Infection. 1980 Sep;8(5 Supplement). https://doi.org/10.1007/BF01639676
Hartstein, A. I. ; Patrick, K. E. ; Jones, S. R. ; Miller, M. J. ; Bryant, Richard. / Comparison of pharmacological and antimicrobial properties of cefadroxil and cephalexin. In: Infection. 1980 ; Vol. 8, No. 5 Supplement.
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