Comparison of percentage of total prostate needle biopsy tissue with cancer to percentage of cores with cancer for predicting PSA recurrence after radical prostatectomy: Results from the SEARCH database

Stephen J. Freedland, William J. Aronson, George S. Csathy, Christopher J. Kane, Christopher Amling, Joseph C. Presti, Frederick Dorey, Martha K. Terris

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objectives. Tumor volume in the prostate needle biopsy is an important prognosticator for patients with prostate cancer. However, the best method to measure tumor volume in the prostate needle biopsy is unknown. We compared the total percentage of biopsy tissue with cancer to the percentage of cores positive for their ability to predict adverse pathologic findings and biochemical failure after radical prostatectomy (RP). Methods. A retrospective survey of 355 patients from the Shared Equal Access Regional Cancer Hospital database treated with RP between 1990 and 2002 was undertaken. Multivariate analysis was used to compare the percentage of cores and percentage of tissue with cancer to the standard clinical variables of age, prostate-specific antigen (PSA) level, biopsy Gleason score, and clinical stage for their ability to predict positive surgical margins, non-organ-confined disease, seminal vesicle invasion, and time to PSA recurrence after RP. Results. On multivariate analysis, the percentage of tissue with cancer significantly predicted non-organ-confined disease and seminal vesicle invasion, but the percentage of cores did not significantly predict any of the pathologic features examined. In separate multivariate analysis, only the percentage of tissue with cancer, but not the percentage of cores with cancer, significantly predicted PSA failure. Moreover, when compared in the same multivariate analysis, only the percentage of tissue with cancer (hazard ratio 8.25, 95% confidence interval 3.06 to 22.22, P

Original languageEnglish (US)
Pages (from-to)742-747
Number of pages6
JournalUrology
Volume61
Issue number4
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

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Needle Biopsy
Prostate-Specific Antigen
Prostatectomy
Prostate
Prostatic Neoplasms
Databases
Recurrence
Multivariate Analysis
Neoplasms
Seminal Vesicles
Tumor Burden
Biopsy
Cancer Care Facilities
Neoplasm Grading
Confidence Intervals

ASJC Scopus subject areas

  • Urology

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Comparison of percentage of total prostate needle biopsy tissue with cancer to percentage of cores with cancer for predicting PSA recurrence after radical prostatectomy : Results from the SEARCH database. / Freedland, Stephen J.; Aronson, William J.; Csathy, George S.; Kane, Christopher J.; Amling, Christopher; Presti, Joseph C.; Dorey, Frederick; Terris, Martha K.

In: Urology, Vol. 61, No. 4, 01.04.2003, p. 742-747.

Research output: Contribution to journalArticle

Freedland, Stephen J. ; Aronson, William J. ; Csathy, George S. ; Kane, Christopher J. ; Amling, Christopher ; Presti, Joseph C. ; Dorey, Frederick ; Terris, Martha K. / Comparison of percentage of total prostate needle biopsy tissue with cancer to percentage of cores with cancer for predicting PSA recurrence after radical prostatectomy : Results from the SEARCH database. In: Urology. 2003 ; Vol. 61, No. 4. pp. 742-747.
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abstract = "Objectives. Tumor volume in the prostate needle biopsy is an important prognosticator for patients with prostate cancer. However, the best method to measure tumor volume in the prostate needle biopsy is unknown. We compared the total percentage of biopsy tissue with cancer to the percentage of cores positive for their ability to predict adverse pathologic findings and biochemical failure after radical prostatectomy (RP). Methods. A retrospective survey of 355 patients from the Shared Equal Access Regional Cancer Hospital database treated with RP between 1990 and 2002 was undertaken. Multivariate analysis was used to compare the percentage of cores and percentage of tissue with cancer to the standard clinical variables of age, prostate-specific antigen (PSA) level, biopsy Gleason score, and clinical stage for their ability to predict positive surgical margins, non-organ-confined disease, seminal vesicle invasion, and time to PSA recurrence after RP. Results. On multivariate analysis, the percentage of tissue with cancer significantly predicted non-organ-confined disease and seminal vesicle invasion, but the percentage of cores did not significantly predict any of the pathologic features examined. In separate multivariate analysis, only the percentage of tissue with cancer, but not the percentage of cores with cancer, significantly predicted PSA failure. Moreover, when compared in the same multivariate analysis, only the percentage of tissue with cancer (hazard ratio 8.25, 95{\%} confidence interval 3.06 to 22.22, P",
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T1 - Comparison of percentage of total prostate needle biopsy tissue with cancer to percentage of cores with cancer for predicting PSA recurrence after radical prostatectomy

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AU - Freedland, Stephen J.

AU - Aronson, William J.

AU - Csathy, George S.

AU - Kane, Christopher J.

AU - Amling, Christopher

AU - Presti, Joseph C.

AU - Dorey, Frederick

AU - Terris, Martha K.

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N2 - Objectives. Tumor volume in the prostate needle biopsy is an important prognosticator for patients with prostate cancer. However, the best method to measure tumor volume in the prostate needle biopsy is unknown. We compared the total percentage of biopsy tissue with cancer to the percentage of cores positive for their ability to predict adverse pathologic findings and biochemical failure after radical prostatectomy (RP). Methods. A retrospective survey of 355 patients from the Shared Equal Access Regional Cancer Hospital database treated with RP between 1990 and 2002 was undertaken. Multivariate analysis was used to compare the percentage of cores and percentage of tissue with cancer to the standard clinical variables of age, prostate-specific antigen (PSA) level, biopsy Gleason score, and clinical stage for their ability to predict positive surgical margins, non-organ-confined disease, seminal vesicle invasion, and time to PSA recurrence after RP. Results. On multivariate analysis, the percentage of tissue with cancer significantly predicted non-organ-confined disease and seminal vesicle invasion, but the percentage of cores did not significantly predict any of the pathologic features examined. In separate multivariate analysis, only the percentage of tissue with cancer, but not the percentage of cores with cancer, significantly predicted PSA failure. Moreover, when compared in the same multivariate analysis, only the percentage of tissue with cancer (hazard ratio 8.25, 95% confidence interval 3.06 to 22.22, P

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