Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals

Joseph Yeboah, Robyn L. McClelland, Tamar S. Polonsky, Gregory L. Burke, Christopher Sibley, Daniel O'Leary, Jeffery J. Carr, David C. Goff, Philip Greenland, David M. Herrington

Research output: Contribution to journalArticle

573 Citations (Scopus)

Abstract

Context: Risk markers including coronary artery calcium, carotid intima-media thickness, ankle-brachial index, brachial flow-mediated dilation, high-sensitivity C-reactive protein (CRP), and family history of coronary heart disease (CHD) have been reported to improve on the Framingham Risk Score (FRS) for prediction of CHD, but there are no direct comparisons of these markers for risk prediction in a single cohort. Objective: We compared improvement in prediction of incident CHD/ cardiovascular disease (CVD) of these 6 risk markers within intermediate-risk participants (FRS >5%-

Original languageEnglish (US)
Pages (from-to)788-795
Number of pages8
JournalJAMA - Journal of the American Medical Association
Volume308
Issue number8
StatePublished - Aug 22 2012
Externally publishedYes

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Coronary Disease
Ankle Brachial Index
Carotid Intima-Media Thickness
C-Reactive Protein
Dilatation
Coronary Vessels
Arm
Cardiovascular Diseases
Calcium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yeboah, J., McClelland, R. L., Polonsky, T. S., Burke, G. L., Sibley, C., O'Leary, D., ... Herrington, D. M. (2012). Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals. JAMA - Journal of the American Medical Association, 308(8), 788-795.

Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals. / Yeboah, Joseph; McClelland, Robyn L.; Polonsky, Tamar S.; Burke, Gregory L.; Sibley, Christopher; O'Leary, Daniel; Carr, Jeffery J.; Goff, David C.; Greenland, Philip; Herrington, David M.

In: JAMA - Journal of the American Medical Association, Vol. 308, No. 8, 22.08.2012, p. 788-795.

Research output: Contribution to journalArticle

Yeboah, J, McClelland, RL, Polonsky, TS, Burke, GL, Sibley, C, O'Leary, D, Carr, JJ, Goff, DC, Greenland, P & Herrington, DM 2012, 'Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals', JAMA - Journal of the American Medical Association, vol. 308, no. 8, pp. 788-795.
Yeboah, Joseph ; McClelland, Robyn L. ; Polonsky, Tamar S. ; Burke, Gregory L. ; Sibley, Christopher ; O'Leary, Daniel ; Carr, Jeffery J. ; Goff, David C. ; Greenland, Philip ; Herrington, David M. / Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals. In: JAMA - Journal of the American Medical Association. 2012 ; Vol. 308, No. 8. pp. 788-795.
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