Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window

Yiliang Zhang, Ru Zhang, Chunfu Dai, Peter S. Steyger, Yu Y. Yongfu

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective/Hypothesis: The distribution of gentamicin in the inner ear via the endolymphatic sac (ES) or round window (RW) routes was investigated. Study Design: Experimental study. Methods: A fluorescent gentamicin-Texas Red conjugate (GTTR) was adopted to visualize the gentamicin. Adult guinea pigs were treated with GTTR applied to the ES or RW, the animals were allowed to recover for 3 days, then confocal microscopy was used to observe and quantify GTTR distributions in cochlear and vestibular sensory epithelium. Results: When GTTR was applied via the ES, strong GTTR labeling was observed in the vestibule while little GTTR was detected in the cochlea (P < .0001). However, distinct GTTR fluorescence was observed in the cochlea and vestibule following RW application (P = .7967). There was less GTTR labeling in cochlea via ES application than through RW administration (P < .0001). Conclusions: ES drug application may be preferable for the treatment of intractable Meniere's disease.

Original languageEnglish (US)
Pages (from-to)2054-2060
Number of pages7
JournalLaryngoscope
Volume120
Issue number10
DOIs
StatePublished - Oct 1 2010

Keywords

  • Endolymphatic sac
  • Gentamicin
  • Meniere's disease
  • Round window

ASJC Scopus subject areas

  • Otorhinolaryngology

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