Comparison of effect of endothelin antagonism and angiotensin- converting enzyme inhibition on blood pressure and vascular structure in spontaneously hypertensive rats treated with N(ω)-nitro-L-arginine methyl ester: Correlation with topography of vascular endothelin-1 gene expression

Jin S. Li, Li Y. Deng, Kevin Grove, Christian F. Deschepper, Ernesto L. Schiffrin

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Inhibition of nitric oxide synthase by L-arginine analogues such as N(ω)-nitro-L-arginine methyl ester (L-NAME) in spontaneously hypertensive rats (SHR) is associated with malignant hypertension and enhanced expression of the endothelin-1 gene in some blood vessels. In this study, SHR treated chronically with L-NAME (SHR-L-NAME) were given the angiotensin 1-converting enzyme inhibitor cilazapril or the endothelin-A/endothelin-B receptor antagonist bosentan for 3 weeks. Systolic pressure was lowered slightly by cilazapril (213±2 versus 229±2 mm Hg in untreated SHR-L-NAME, P

Original languageEnglish (US)
Pages (from-to)188-195
Number of pages8
JournalHypertension
Volume28
Issue number2
StatePublished - Aug 1996
Externally publishedYes

Fingerprint

Endothelins
NG-Nitroarginine Methyl Ester
Endothelin-1
Peptidyl-Dipeptidase A
Inbred SHR Rats
Cilazapril
Blood Vessels
Blood Pressure
Gene Expression
Malignant Hypertension
Angiotensin-Converting Enzyme Inhibitors
Nitric Oxide Synthase
Arginine
Genes
arginine methyl ester

Keywords

  • aorta
  • endothelium-derived factor
  • nitric oxide
  • receptors, endothelin
  • resistance vessels

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Comparison of effect of endothelin antagonism and angiotensin- converting enzyme inhibition on blood pressure and vascular structure in spontaneously hypertensive rats treated with N(ω)-nitro-L-arginine methyl ester: Correlation with topography of vascular endothelin-1 gene expression",
abstract = "Inhibition of nitric oxide synthase by L-arginine analogues such as N(ω)-nitro-L-arginine methyl ester (L-NAME) in spontaneously hypertensive rats (SHR) is associated with malignant hypertension and enhanced expression of the endothelin-1 gene in some blood vessels. In this study, SHR treated chronically with L-NAME (SHR-L-NAME) were given the angiotensin 1-converting enzyme inhibitor cilazapril or the endothelin-A/endothelin-B receptor antagonist bosentan for 3 weeks. Systolic pressure was lowered slightly by cilazapril (213±2 versus 229±2 mm Hg in untreated SHR-L-NAME, P",
keywords = "aorta, endothelium-derived factor, nitric oxide, receptors, endothelin, resistance vessels",
author = "Li, {Jin S.} and Deng, {Li Y.} and Kevin Grove and Deschepper, {Christian F.} and Schiffrin, {Ernesto L.}",
year = "1996",
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T1 - Comparison of effect of endothelin antagonism and angiotensin- converting enzyme inhibition on blood pressure and vascular structure in spontaneously hypertensive rats treated with N(ω)-nitro-L-arginine methyl ester

T2 - Correlation with topography of vascular endothelin-1 gene expression

AU - Li, Jin S.

AU - Deng, Li Y.

AU - Grove, Kevin

AU - Deschepper, Christian F.

AU - Schiffrin, Ernesto L.

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Y1 - 1996/8

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AB - Inhibition of nitric oxide synthase by L-arginine analogues such as N(ω)-nitro-L-arginine methyl ester (L-NAME) in spontaneously hypertensive rats (SHR) is associated with malignant hypertension and enhanced expression of the endothelin-1 gene in some blood vessels. In this study, SHR treated chronically with L-NAME (SHR-L-NAME) were given the angiotensin 1-converting enzyme inhibitor cilazapril or the endothelin-A/endothelin-B receptor antagonist bosentan for 3 weeks. Systolic pressure was lowered slightly by cilazapril (213±2 versus 229±2 mm Hg in untreated SHR-L-NAME, P

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KW - resistance vessels

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