Comparison of cerebral blood flow and structural penumbras in relation to white matter hyperintensities

A multi-modal magnetic resonance imaging study

Nutta On Promjunyakul, David L. Lahna, Jeffrey Kaye, Hiroko Dodge, Deniz Erten-Lyons, William Rooney, Lisa Silbert

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Normal-appearing white matter (NAWM) surrounding WMHs is associated with decreased structural integrity and perfusion, increased risk of WMH growth, and is referred to as the WMH penumbra. Studies comparing structural and cerebral blood flow (CBF) penumbras within the same individuals are lacking, however, and would facilitate our understanding of mechanisms resulting in WM damage. This study aimed to compare both CBF and structural WMH penumbras in non-demented aging. Eighty-two elderly volunteers underwent 3T-MRI including fluid attenuated inversion recovery (FLAIR), pulsed arterial spin labeling and diffusion tensor imaging (DTI). A NAWM layer mask was generated for periventricular and deep WMHs. Mean CBF, DTI-fractional anisotropy (DTI-FA), DTI-mean diffusivity (DTI-MD) and FLAIR intensity for WMHs and its corresponding NAWM layer masks were computed and compared against its mean within total brain NAWM using mixed effects models. For both periventricular and deep WMHs, DTI-FA, DTI-MD and FLAIR intensity changes extended 2-9 mm surrounding WMHs (p ≤ 0.05), while CBF changes extended 13-14 mm (p ≤ 0.05). The CBF penumbra is more extensive than structural penumbras in relation to WMHs and includes WM tissue both with and without microstructural changes. Findings implicate CBF as a potential target for the prevention of both micro and macro structural WM damage.

Original languageEnglish (US)
Pages (from-to)1528-1536
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume36
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Cerebrovascular Circulation
Diffusion Tensor Imaging
Magnetic Resonance Imaging
Masks
Anisotropy
White Matter
Volunteers
Perfusion
Brain
Growth

Keywords

  • aging
  • Arterial spin labeling
  • cerebral blood flow
  • diffusion tensor imaging
  • magnetic resonance imaging
  • vascular cognitive impairment

ASJC Scopus subject areas

  • Medicine(all)
  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Comparison of cerebral blood flow and structural penumbras in relation to white matter hyperintensities: A multi-modal magnetic resonance imaging study",
abstract = "Normal-appearing white matter (NAWM) surrounding WMHs is associated with decreased structural integrity and perfusion, increased risk of WMH growth, and is referred to as the WMH penumbra. Studies comparing structural and cerebral blood flow (CBF) penumbras within the same individuals are lacking, however, and would facilitate our understanding of mechanisms resulting in WM damage. This study aimed to compare both CBF and structural WMH penumbras in non-demented aging. Eighty-two elderly volunteers underwent 3T-MRI including fluid attenuated inversion recovery (FLAIR), pulsed arterial spin labeling and diffusion tensor imaging (DTI). A NAWM layer mask was generated for periventricular and deep WMHs. Mean CBF, DTI-fractional anisotropy (DTI-FA), DTI-mean diffusivity (DTI-MD) and FLAIR intensity for WMHs and its corresponding NAWM layer masks were computed and compared against its mean within total brain NAWM using mixed effects models. For both periventricular and deep WMHs, DTI-FA, DTI-MD and FLAIR intensity changes extended 2-9 mm surrounding WMHs (p ≤ 0.05), while CBF changes extended 13-14 mm (p ≤ 0.05). The CBF penumbra is more extensive than structural penumbras in relation to WMHs and includes WM tissue both with and without microstructural changes. Findings implicate CBF as a potential target for the prevention of both micro and macro structural WM damage.",
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T1 - Comparison of cerebral blood flow and structural penumbras in relation to white matter hyperintensities

T2 - A multi-modal magnetic resonance imaging study

AU - Promjunyakul, Nutta On

AU - Lahna, David L.

AU - Kaye, Jeffrey

AU - Dodge, Hiroko

AU - Erten-Lyons, Deniz

AU - Rooney, William

AU - Silbert, Lisa

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