Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats

Richard Parker, D. N. Gilbert, Donald Houghton, G. A. Porter, W. M. Bennett

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days in rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.

Original languageEnglish (US)
Pages (from-to)346-348
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume18
Issue number2
StatePublished - 1980

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Netilmicin
Tobramycin
Kidney
Mortality

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Parker, R., Gilbert, D. N., Houghton, D., Porter, G. A., & Bennett, W. M. (1980). Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats. Antimicrobial Agents and Chemotherapy, 18(2), 346-348.

Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats. / Parker, Richard; Gilbert, D. N.; Houghton, Donald; Porter, G. A.; Bennett, W. M.

In: Antimicrobial Agents and Chemotherapy, Vol. 18, No. 2, 1980, p. 346-348.

Research output: Contribution to journalArticle

Parker, R, Gilbert, DN, Houghton, D, Porter, GA & Bennett, WM 1980, 'Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats', Antimicrobial Agents and Chemotherapy, vol. 18, no. 2, pp. 346-348.
Parker, Richard ; Gilbert, D. N. ; Houghton, Donald ; Porter, G. A. ; Bennett, W. M. / Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats. In: Antimicrobial Agents and Chemotherapy. 1980 ; Vol. 18, No. 2. pp. 346-348.
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