Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha

Aaron Hardin, Kimberly A. Nevonen, Walter L. Eckalbar, Lucia Carbone, Nadav Ahituv

Research output: Contribution to journalArticle

Abstract

Mastomys are the most widespread African rodent and carriers of various diseases such as the plague or Lassa virus. In addition, mastomys have rapidly gained a large number of mammary glands. Here, we generated a genome, variome, and transcriptomes for Mastomys coucha. As mastomys diverged at similar times from mouse and rat, we demonstrate their utility as a comparative genomic tool for these commonly used animal models. Furthermore, we identified over 500 mastomys accelerated regions, often residing near important mammary developmental genes or within their exons leading to protein sequence changes. Functional characterization of a noncoding mastomys accelerated region, located in the HoxD locus, showed enhancer activity in mouse developing mammary glands. Combined, our results provide genomic resources for mastomys and highlight their potential both as a comparative genomic tool and for the identification of mammary gland number determining factors.

Original languageEnglish (US)
Pages (from-to)2805-2812
Number of pages8
JournalMolecular Biology and Evolution
Volume36
Issue number12
DOIs
StatePublished - Dec 1 2019

Fingerprint

Mastomys
Murinae
genomics
mice
Human Mammary Glands
mammary glands
rodent
virus
genome
Lassa virus
protein
gene
animal
Developmental Genes
carrier state
resource
Plague
plague
Transcriptome
transcriptome

Keywords

  • Comparative genomics
  • mammary glands
  • Mastomys

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha. / Hardin, Aaron; Nevonen, Kimberly A.; Eckalbar, Walter L.; Carbone, Lucia; Ahituv, Nadav.

In: Molecular Biology and Evolution, Vol. 36, No. 12, 01.12.2019, p. 2805-2812.

Research output: Contribution to journalArticle

Hardin, Aaron ; Nevonen, Kimberly A. ; Eckalbar, Walter L. ; Carbone, Lucia ; Ahituv, Nadav. / Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha. In: Molecular Biology and Evolution. 2019 ; Vol. 36, No. 12. pp. 2805-2812.
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