Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection

Shanshan Liang, Arya Saidi, Joe Jing, Gangjun Liu, Jiechen Yin, Jagat Narula, Zhongping Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Coronary heart disease (like myocardial infarction) is caused by atherosclerosis. It cause over 30% of all deaths in North America and are the most common cause of death in European men under 65 years of age and the second most common cause in women. To diagnose this atherosclerosis before it gets rupture is the most effect way to increase the chance of survival for patients who suffer from this disease. The crucial tusk is how to find out vulnerable plaques. In resent years optical coherence tomography (OCT) has become a very useful tool for intravascular imaging, since it has high axial and transverse resolution. OCT can tell the detail structure inside the plaque like the thickness of plaque cap which is an important factor to identify vulnerable plaques. But we still need to find out the biochemical characteristics that is unique for vulnerable plaques (like inflammation). Fluorescence molecular imaging is a standard way to exam the biochemical property of biological samples. So we integrate these two techniques together into one probe. Our probe is comprised of a double-clad fiber (DCF) and a grin lens, and rotates with a micro mirror in front. The single-mode inner core of the DCF transmits both OCT and fluorescence excitation light, and the multimode inner cladding is used to detect fluorescence signal. In vitro result shows that this is a possible way for more accurate diagnose of vulnerable plaques.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8207
DOIs
StatePublished - 2012
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: Jan 21 2012Jan 24 2012

Other

OtherPhotonic Therapeutics and Diagnostics VIII
CountryUnited States
CitySan Francisco, CA
Period1/21/121/24/12

Fingerprint

arteriosclerosis
Optical Imaging
Optical tomography
Optical Coherence Tomography
Atherosclerosis
tomography
Fluorescence
Imaging techniques
death
fluorescence
causes
myocardial infarction
heart diseases
Molecular imaging
Molecular Imaging
fibers
Fibers
probes
North America
caps

Keywords

  • Double-clad fiber
  • Fluorescence
  • OCT
  • Vulnerable plaque

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Liang, S., Saidi, A., Jing, J., Liu, G., Yin, J., Narula, J., & Chen, Z. (2012). Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8207). [82073Y] https://doi.org/10.1117/12.907836

Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection. / Liang, Shanshan; Saidi, Arya; Jing, Joe; Liu, Gangjun; Yin, Jiechen; Narula, Jagat; Chen, Zhongping.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012. 82073Y.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liang, S, Saidi, A, Jing, J, Liu, G, Yin, J, Narula, J & Chen, Z 2012, Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8207, 82073Y, Photonic Therapeutics and Diagnostics VIII, San Francisco, CA, United States, 1/21/12. https://doi.org/10.1117/12.907836
Liang S, Saidi A, Jing J, Liu G, Yin J, Narula J et al. Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207. 2012. 82073Y https://doi.org/10.1117/12.907836
Liang, Shanshan ; Saidi, Arya ; Jing, Joe ; Liu, Gangjun ; Yin, Jiechen ; Narula, Jagat ; Chen, Zhongping. / Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012.
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