Combinatorial roles of the nuclear receptor corepressor in transcription and development

Kristen Jepsen, Ola Hermanson, Thandi M. Onami, Anatoli S. Gleiberman, Victoria Lunyak, Robert J. McEvilly, Riki Kurokawa, Vivek Kumar, Forrest Liu, Edward Seto, Stephen M. Hedrick, Gail Mandel, Christopher K. Glass, David W. Rose, Michael G. Rosenfeld

Research output: Contribution to journalArticle

377 Citations (Scopus)

Abstract

Transcriptional repression plays crucial roles in diverse aspects of metazoan development, implying critical regulatory roles for corepressors such as N-CoR and SMRT. Altered patterns of transcription in tissues and cells derived from N-CoR gene-deleted mice and the resulting block at specific points in CNS, erythrocyte, and thymocyte development indicated that N-CoR was a required component of short-term active repression by nuclear receptors and MAD and of a subset of long-term repression events mediated by REST/NRSF. Unexpectedly, N-CoR and a specific deacetylase were also required for transcriptional activation of one class of retinoic acid response element. Together, these findings suggest that specific combinations of corepressors and histone deacetylases mediate the gene-specific actions of DNA-bound repressors in development of multiple organ systems.

Original languageEnglish (US)
Pages (from-to)753-763
Number of pages11
JournalCell
Volume102
Issue number6
StatePublished - Sep 15 2000
Externally publishedYes

Fingerprint

Co-Repressor Proteins
Transcription
Genes
Histone Deacetylases
Response Elements
Thymocytes
Cytoplasmic and Nuclear Receptors
Tretinoin
Transcriptional Activation
Erythrocytes
Chemical activation
Tissue
DNA
mycophenolic adenine dinucleotide

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Jepsen, K., Hermanson, O., Onami, T. M., Gleiberman, A. S., Lunyak, V., McEvilly, R. J., ... Rosenfeld, M. G. (2000). Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell, 102(6), 753-763.

Combinatorial roles of the nuclear receptor corepressor in transcription and development. / Jepsen, Kristen; Hermanson, Ola; Onami, Thandi M.; Gleiberman, Anatoli S.; Lunyak, Victoria; McEvilly, Robert J.; Kurokawa, Riki; Kumar, Vivek; Liu, Forrest; Seto, Edward; Hedrick, Stephen M.; Mandel, Gail; Glass, Christopher K.; Rose, David W.; Rosenfeld, Michael G.

In: Cell, Vol. 102, No. 6, 15.09.2000, p. 753-763.

Research output: Contribution to journalArticle

Jepsen, K, Hermanson, O, Onami, TM, Gleiberman, AS, Lunyak, V, McEvilly, RJ, Kurokawa, R, Kumar, V, Liu, F, Seto, E, Hedrick, SM, Mandel, G, Glass, CK, Rose, DW & Rosenfeld, MG 2000, 'Combinatorial roles of the nuclear receptor corepressor in transcription and development', Cell, vol. 102, no. 6, pp. 753-763.
Jepsen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ et al. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 2000 Sep 15;102(6):753-763.
Jepsen, Kristen ; Hermanson, Ola ; Onami, Thandi M. ; Gleiberman, Anatoli S. ; Lunyak, Victoria ; McEvilly, Robert J. ; Kurokawa, Riki ; Kumar, Vivek ; Liu, Forrest ; Seto, Edward ; Hedrick, Stephen M. ; Mandel, Gail ; Glass, Christopher K. ; Rose, David W. ; Rosenfeld, Michael G. / Combinatorial roles of the nuclear receptor corepressor in transcription and development. In: Cell. 2000 ; Vol. 102, No. 6. pp. 753-763.
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