Columnar specificity of microvascular oxygenation and blood flow response in primary visual cortex

Evaluation by local field potential and spiking activity

Zheng Wang, Anna Roe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The relation of cortical microcirculation, oxygen metabolism, and underlying neuronal network activity remains poorly understood. Anatomical distribution of cortical microvasculature and its relationship to cortical functional domains suggests that functional organizations may be revealed by mapping cerebral blood flow responses. However, there is little direct experimental evidence and a lack of electrophysiological evaluation. In this study, we mapped ocular-dominance columns in primary visual cortex (V1) of anesthetized macaques with capillary flow-based laser speckle contrast imaging and deoxyhemoglobin-based intrinsic optical imaging. In parallel, the local field potentials (LFPs) and spikes were recorded from a linear array of eight microelectrodes, carefully positioned into left and right eye columns in V1. We found differential activation maps of blood flow, after masking large superficial draining vessels, exhibited a column-like pattern similar as the oximetric maps. Both the activated spikes and γ-band LFP demonstrated corresponding eye preference, consistent with the imaging maps. Our results present direct support in favor of previous proposals that the regulation of microcirculation can be as fine as the submillimeter scale, suggesting that cortical vasculature is functionally organized at the columnar level in a manner appropriate for supplying energy demands of functionally specific neuronal populations.

Original languageEnglish (US)
Pages (from-to)6-16
Number of pages11
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Visual Cortex
Microcirculation
Cerebrovascular Circulation
ocular Dominance
Optical Imaging
Macaca
Microelectrodes
Microvessels
Action Potentials
Lasers
Oxygen
Population
deoxyhemoglobin

Keywords

  • cortical mapping
  • electrophysiology
  • functional MRI
  • neurovascular coupling
  • ocular dominance
  • optical imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

@article{6869db5fcf9542cdb688573c508f0932,
title = "Columnar specificity of microvascular oxygenation and blood flow response in primary visual cortex: Evaluation by local field potential and spiking activity",
abstract = "The relation of cortical microcirculation, oxygen metabolism, and underlying neuronal network activity remains poorly understood. Anatomical distribution of cortical microvasculature and its relationship to cortical functional domains suggests that functional organizations may be revealed by mapping cerebral blood flow responses. However, there is little direct experimental evidence and a lack of electrophysiological evaluation. In this study, we mapped ocular-dominance columns in primary visual cortex (V1) of anesthetized macaques with capillary flow-based laser speckle contrast imaging and deoxyhemoglobin-based intrinsic optical imaging. In parallel, the local field potentials (LFPs) and spikes were recorded from a linear array of eight microelectrodes, carefully positioned into left and right eye columns in V1. We found differential activation maps of blood flow, after masking large superficial draining vessels, exhibited a column-like pattern similar as the oximetric maps. Both the activated spikes and γ-band LFP demonstrated corresponding eye preference, consistent with the imaging maps. Our results present direct support in favor of previous proposals that the regulation of microcirculation can be as fine as the submillimeter scale, suggesting that cortical vasculature is functionally organized at the columnar level in a manner appropriate for supplying energy demands of functionally specific neuronal populations.",
keywords = "cortical mapping, electrophysiology, functional MRI, neurovascular coupling, ocular dominance, optical imaging",
author = "Zheng Wang and Anna Roe",
year = "2012",
month = "1",
doi = "10.1038/jcbfm.2011.152",
language = "English (US)",
volume = "32",
pages = "6--16",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Columnar specificity of microvascular oxygenation and blood flow response in primary visual cortex

T2 - Evaluation by local field potential and spiking activity

AU - Wang, Zheng

AU - Roe, Anna

PY - 2012/1

Y1 - 2012/1

N2 - The relation of cortical microcirculation, oxygen metabolism, and underlying neuronal network activity remains poorly understood. Anatomical distribution of cortical microvasculature and its relationship to cortical functional domains suggests that functional organizations may be revealed by mapping cerebral blood flow responses. However, there is little direct experimental evidence and a lack of electrophysiological evaluation. In this study, we mapped ocular-dominance columns in primary visual cortex (V1) of anesthetized macaques with capillary flow-based laser speckle contrast imaging and deoxyhemoglobin-based intrinsic optical imaging. In parallel, the local field potentials (LFPs) and spikes were recorded from a linear array of eight microelectrodes, carefully positioned into left and right eye columns in V1. We found differential activation maps of blood flow, after masking large superficial draining vessels, exhibited a column-like pattern similar as the oximetric maps. Both the activated spikes and γ-band LFP demonstrated corresponding eye preference, consistent with the imaging maps. Our results present direct support in favor of previous proposals that the regulation of microcirculation can be as fine as the submillimeter scale, suggesting that cortical vasculature is functionally organized at the columnar level in a manner appropriate for supplying energy demands of functionally specific neuronal populations.

AB - The relation of cortical microcirculation, oxygen metabolism, and underlying neuronal network activity remains poorly understood. Anatomical distribution of cortical microvasculature and its relationship to cortical functional domains suggests that functional organizations may be revealed by mapping cerebral blood flow responses. However, there is little direct experimental evidence and a lack of electrophysiological evaluation. In this study, we mapped ocular-dominance columns in primary visual cortex (V1) of anesthetized macaques with capillary flow-based laser speckle contrast imaging and deoxyhemoglobin-based intrinsic optical imaging. In parallel, the local field potentials (LFPs) and spikes were recorded from a linear array of eight microelectrodes, carefully positioned into left and right eye columns in V1. We found differential activation maps of blood flow, after masking large superficial draining vessels, exhibited a column-like pattern similar as the oximetric maps. Both the activated spikes and γ-band LFP demonstrated corresponding eye preference, consistent with the imaging maps. Our results present direct support in favor of previous proposals that the regulation of microcirculation can be as fine as the submillimeter scale, suggesting that cortical vasculature is functionally organized at the columnar level in a manner appropriate for supplying energy demands of functionally specific neuronal populations.

KW - cortical mapping

KW - electrophysiology

KW - functional MRI

KW - neurovascular coupling

KW - ocular dominance

KW - optical imaging

UR - http://www.scopus.com/inward/record.url?scp=84855381460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855381460&partnerID=8YFLogxK

U2 - 10.1038/jcbfm.2011.152

DO - 10.1038/jcbfm.2011.152

M3 - Article

VL - 32

SP - 6

EP - 16

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 1

ER -