Colorectal chemoprevention pilot study (SWOG-9041), randomized and placebo controlled: The importance of multiple luminal lesions

David Z.J. Chu; Michael A. Hussey; David S. Alberts; Frank L. Meyskens; Cecilia M. Fenoglio-Preiser; Saul E. Rivkin; Glenn M. Mills; Jeffrey K. Giguere; Charles D. Blanke; Gary E. Goodman

doi:10.1016/j.clcc.2011.06.005

Colorectal chemoprevention pilot study (SWOG-9041), randomized and placebo controlled: The importance of multiple luminal lesions

David Z.J. Chu, Michael A. Hussey, David S. Alberts, Frank L. Meyskens, Cecilia M. Fenoglio-Preiser, Saul E. Rivkin, Glenn M. Mills, Jeffrey K. Giguere, Charles D. Blanke, Gary E. Goodman

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Background: Colorectal cancer is common worldwide and chemoprevention has the potential of reducing the number of individuals who may suffer and perish from this disease. Methods: A randomized placebo controlled pilot study in colorectal cancer patients was performed using calcium carbonate as the test agent in a multi-institutional oncology study group. Results: Two hundred twenty volunteers were randomized in the study. The primary goals of compliance, accrual, and toxicity monitoring are presented. Presence of multiple adenomas at study entry and subsequent development of metachronous adenomas were recorded and found to be associated with synchronous adenomas. The secondary endpoint of recurrent adenomas indicated lower rates of new adenoma in the volunteers randomized to the calcium group. Conclusion: This pilot study indicates the feasibility of enrolling survivors of colorectal cancer as study volunteers in a colorectal neoplasm chemoprevention clinical trial and oral calcium continues to be a potentially effective drug in reducing colorectal adenomas.

Original language	English (US)
Pages (from-to)	310-316
Number of pages	7
Journal	Clinical Colorectal Cancer
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/j.clcc.2011.06.005
State	Published - Dec 2011
Externally published	Yes

Keywords

Calcium carbonate
Metachronous adenomas
Synchronous adenomas

ASJC Scopus subject areas

Oncology
Gastroenterology

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10.1016/j.clcc.2011.06.005

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Chu, D. Z. J., Hussey, M. A., Alberts, D. S., Meyskens, F. L., Fenoglio-Preiser, C. M., Rivkin, S. E., Mills, G. M., Giguere, J. K., Blanke, C. D., & Goodman, G. E. (2011). Colorectal chemoprevention pilot study (SWOG-9041), randomized and placebo controlled: The importance of multiple luminal lesions. Clinical Colorectal Cancer, 10(4), 310-316. https://doi.org/10.1016/j.clcc.2011.06.005

Chu, DZJ, Hussey, MA, Alberts, DS, Meyskens, FL, Fenoglio-Preiser, CM, Rivkin, SE, Mills, GM, Giguere, JK, Blanke, CD & Goodman, GE 2011, 'Colorectal chemoprevention pilot study (SWOG-9041), randomized and placebo controlled: The importance of multiple luminal lesions', Clinical Colorectal Cancer, vol. 10, no. 4, pp. 310-316. https://doi.org/10.1016/j.clcc.2011.06.005

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abstract = "Background: Colorectal cancer is common worldwide and chemoprevention has the potential of reducing the number of individuals who may suffer and perish from this disease. Methods: A randomized placebo controlled pilot study in colorectal cancer patients was performed using calcium carbonate as the test agent in a multi-institutional oncology study group. Results: Two hundred twenty volunteers were randomized in the study. The primary goals of compliance, accrual, and toxicity monitoring are presented. Presence of multiple adenomas at study entry and subsequent development of metachronous adenomas were recorded and found to be associated with synchronous adenomas. The secondary endpoint of recurrent adenomas indicated lower rates of new adenoma in the volunteers randomized to the calcium group. Conclusion: This pilot study indicates the feasibility of enrolling survivors of colorectal cancer as study volunteers in a colorectal neoplasm chemoprevention clinical trial and oral calcium continues to be a potentially effective drug in reducing colorectal adenomas.",

keywords = "Calcium carbonate, Metachronous adenomas, Synchronous adenomas",

author = "Chu, {David Z.J.} and Hussey, {Michael A.} and Alberts, {David S.} and Meyskens, {Frank L.} and Fenoglio-Preiser, {Cecilia M.} and Rivkin, {Saul E.} and Mills, {Glenn M.} and Giguere, {Jeffrey K.} and Blanke, {Charles D.} and Goodman, {Gary E.}",

note = "Funding Information: This investigation was supported in part by the following PHS Cooperative Agreement grant numbers awarded by the National Cancer Institute, DHHS : CA32102 , CA38926 , CA20319 , CA58658 , CA67663 , CA35431 , CA67575 , CA63844 , CA27057 , CA45377 , CA46368 , CA35261 , CA63845 , CA46113 , CA76429 , CA13612 , CA35178 , CA42777 , CA74647 , CA45807 , CA63850 , CA28862 , CA12644 , CA35262 , CA22433 , CA76447 , CA58415 , CA12213 , CA35192 , CA14028 , CA45450 , CA58416 , CA37981 , CA35090 , CA35281 , CA45560 , CA52757 , CA04919 , CA35176 , CA52772 , CA46441 , CA58723 , CA52654 , CA68183 .",

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doi = "10.1016/j.clcc.2011.06.005",

language = "English (US)",

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T1 - Colorectal chemoprevention pilot study (SWOG-9041), randomized and placebo controlled

T2 - The importance of multiple luminal lesions

AU - Chu, David Z.J.

AU - Hussey, Michael A.

AU - Alberts, David S.

AU - Meyskens, Frank L.

AU - Fenoglio-Preiser, Cecilia M.

AU - Rivkin, Saul E.

AU - Mills, Glenn M.

AU - Giguere, Jeffrey K.

AU - Blanke, Charles D.

AU - Goodman, Gary E.

N1 - Funding Information: This investigation was supported in part by the following PHS Cooperative Agreement grant numbers awarded by the National Cancer Institute, DHHS : CA32102 , CA38926 , CA20319 , CA58658 , CA67663 , CA35431 , CA67575 , CA63844 , CA27057 , CA45377 , CA46368 , CA35261 , CA63845 , CA46113 , CA76429 , CA13612 , CA35178 , CA42777 , CA74647 , CA45807 , CA63850 , CA28862 , CA12644 , CA35262 , CA22433 , CA76447 , CA58415 , CA12213 , CA35192 , CA14028 , CA45450 , CA58416 , CA37981 , CA35090 , CA35281 , CA45560 , CA52757 , CA04919 , CA35176 , CA52772 , CA46441 , CA58723 , CA52654 , CA68183 .

PY - 2011/12

Y1 - 2011/12

N2 - Background: Colorectal cancer is common worldwide and chemoprevention has the potential of reducing the number of individuals who may suffer and perish from this disease. Methods: A randomized placebo controlled pilot study in colorectal cancer patients was performed using calcium carbonate as the test agent in a multi-institutional oncology study group. Results: Two hundred twenty volunteers were randomized in the study. The primary goals of compliance, accrual, and toxicity monitoring are presented. Presence of multiple adenomas at study entry and subsequent development of metachronous adenomas were recorded and found to be associated with synchronous adenomas. The secondary endpoint of recurrent adenomas indicated lower rates of new adenoma in the volunteers randomized to the calcium group. Conclusion: This pilot study indicates the feasibility of enrolling survivors of colorectal cancer as study volunteers in a colorectal neoplasm chemoprevention clinical trial and oral calcium continues to be a potentially effective drug in reducing colorectal adenomas.

AB - Background: Colorectal cancer is common worldwide and chemoprevention has the potential of reducing the number of individuals who may suffer and perish from this disease. Methods: A randomized placebo controlled pilot study in colorectal cancer patients was performed using calcium carbonate as the test agent in a multi-institutional oncology study group. Results: Two hundred twenty volunteers were randomized in the study. The primary goals of compliance, accrual, and toxicity monitoring are presented. Presence of multiple adenomas at study entry and subsequent development of metachronous adenomas were recorded and found to be associated with synchronous adenomas. The secondary endpoint of recurrent adenomas indicated lower rates of new adenoma in the volunteers randomized to the calcium group. Conclusion: This pilot study indicates the feasibility of enrolling survivors of colorectal cancer as study volunteers in a colorectal neoplasm chemoprevention clinical trial and oral calcium continues to be a potentially effective drug in reducing colorectal adenomas.

KW - Calcium carbonate

KW - Metachronous adenomas

KW - Synchronous adenomas

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Colorectal chemoprevention pilot study (SWOG-9041), randomized and placebo controlled: The importance of multiple luminal lesions

Abstract

Keywords

ASJC Scopus subject areas

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