Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA

Courtney Williams, Wenyan Chen, Chia Hsueh Lee, Daniel Yaeger, Nicholas P. Vyleta, Stephen Smith

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Voltage-activated Ca 2+ channels (VACCs) mediate Ca 2+ influx to trigger action potentialg-evoked neurotransmitter release, but the mechanism by which Ca 2+ regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type.

Original languageEnglish (US)
Pages (from-to)1195-1197
Number of pages3
JournalNature Neuroscience
Volume15
Issue number9
DOIs
StatePublished - Sep 2012

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Calcium Channels
Synapses
gamma-Aminobutyric Acid
Action Potentials
Neurotransmitter Agents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. / Williams, Courtney; Chen, Wenyan; Lee, Chia Hsueh; Yaeger, Daniel; Vyleta, Nicholas P.; Smith, Stephen.

In: Nature Neuroscience, Vol. 15, No. 9, 09.2012, p. 1195-1197.

Research output: Contribution to journalArticle

Williams, Courtney ; Chen, Wenyan ; Lee, Chia Hsueh ; Yaeger, Daniel ; Vyleta, Nicholas P. ; Smith, Stephen. / Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. In: Nature Neuroscience. 2012 ; Vol. 15, No. 9. pp. 1195-1197.
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