Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes

Jason M. Link, Harry W. Schroeder

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The role of autoantibodies in the etiology of autoimmune diseases remains unclear. However, an examination of the sequences of these autoantibodies can be informative. Antibody sequences that violate constraints normally imposed during ontogeny and during development point to a failure of regulation. The existence of clonally related sequences indicates that production of these antibodies may frequently be driven by self-antigen. A better understanding of the mechanisms that normally constrain the composition of the antibody repertoire and of the nature of the inciting and/or driving antigens may yield new insights into both the pathogenesis and potential treatment of these crippling diseases.

Original languageEnglish (US)
Pages (from-to)80-83
Number of pages4
JournalArthritis Research
Volume4
Issue number2
DOIs
StatePublished - 2002

Keywords

  • Autoantibody
  • B cell
  • Development
  • Immunoglobulin genes
  • Sequence analysis

ASJC Scopus subject areas

  • Rheumatology

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