Clozapine and seizures

Donald (Duane) Denney, Janice R. Stevens

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Epileptiform EEG changes, myoclonus, and seizures are reported in some patients treated with clozapine. Although these are undesirable side effects, the excitation of specific neuronal networks by clozapine and other neuroleptics may be important for the therapeutic effect of this class of agents. In these experiments, intraperitoneal clozapine 2-16 mg/kg produced dose-related myoclonic jerks in partially restrained rats. Paroxysmal slow waves and spike activity were recorded from implanted electrodes in amygdala, hippocampus, and cortex following higher doses of clozapine, but the EEG abnormalities were not correlated with the myoclonic jerks. Single doses of chlorpromazine (8 and 16 mg/kg) rarely produced myoclonic jerks but provoked generalized tonic seizures in two animals preceded by multiple myoclonic jerks in one. Myoclonus and seizures reflect increased excitability of the central nervous system. It is possible that clozapine and other neuroleptics exert a therapeutic effect by increasing excitability in critical subcortical areas of the brain.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalBiological Psychiatry
Volume37
Issue number7
DOIs
StatePublished - Apr 1 1995

Fingerprint

Myoclonus
Clozapine
Seizures
Therapeutic Uses
Antipsychotic Agents
Electroencephalography
Implanted Electrodes
Chlorpromazine
Amygdala
Hippocampus
Central Nervous System
Brain

Keywords

  • clozapine
  • EEG
  • implanted electrodes
  • myoclonus
  • Rats
  • seizures

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Clozapine and seizures. / Denney, Donald (Duane); Stevens, Janice R.

In: Biological Psychiatry, Vol. 37, No. 7, 01.04.1995, p. 427-433.

Research output: Contribution to journalArticle

Denney, Donald (Duane) ; Stevens, Janice R. / Clozapine and seizures. In: Biological Psychiatry. 1995 ; Vol. 37, No. 7. pp. 427-433.
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