Clonal evolution in atypical chronic granulocytic leukemia: A non-Philadelphia translocation

G. C. Bagby, B. Kaiser-McCaw, F. Hecht, R. D. Koler, J. W. Linman

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Hemopoietic cells in chronic granulocytic leukemia (CGL) frequently contain a chromosome translocation involving chromosome 22 and another autosome, usually number 9. The translocated chromosome 22 is known as the Philadelphia (Ph) chromosome. The appearance of a second Ph chromosome is the most common cytogenetic abnormality in CGL signaling the blastic phase. For 6 yr we serially studied a man with atypical CGL whose marrow cells were marked by a translocation from chromosome 18 to chromosome 11 [46XY, t(11;18) (q23;q12)]. Three months prior to blast transformation there appeared an extra copy of the marker chromosome 18: 47XY,t(11;18) (q23;q12), + (18p11 →18q12). This man presents a new cytogenetic pattern of clonal evolution in CGL. The pattern is analogous to that of the Ph chromosome and is characterized by a balanced chromosomal rearrangement and the subsequent acquisition of an extra copy of the small translocation chromosome immediately prior to blast transformation.

    Original languageEnglish (US)
    Pages (from-to)997-1004
    Number of pages8
    JournalBlood
    Volume51
    Issue number6
    StatePublished - 1978

    Fingerprint

    Clonal Evolution
    Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    Chromosomes
    Philadelphia Chromosome
    Chromosomes, Human, Pair 18
    Chromosomes, Human, Pair 22
    Lymphocyte Activation
    Chromosomes, Human, Pair 11
    Cytogenetics
    Chromosome Aberrations
    Bone Marrow
    Cells

    ASJC Scopus subject areas

    • Hematology

    Cite this

    Bagby, G. C., Kaiser-McCaw, B., Hecht, F., Koler, R. D., & Linman, J. W. (1978). Clonal evolution in atypical chronic granulocytic leukemia: A non-Philadelphia translocation. Blood, 51(6), 997-1004.

    Clonal evolution in atypical chronic granulocytic leukemia : A non-Philadelphia translocation. / Bagby, G. C.; Kaiser-McCaw, B.; Hecht, F.; Koler, R. D.; Linman, J. W.

    In: Blood, Vol. 51, No. 6, 1978, p. 997-1004.

    Research output: Contribution to journalArticle

    Bagby, GC, Kaiser-McCaw, B, Hecht, F, Koler, RD & Linman, JW 1978, 'Clonal evolution in atypical chronic granulocytic leukemia: A non-Philadelphia translocation', Blood, vol. 51, no. 6, pp. 997-1004.
    Bagby GC, Kaiser-McCaw B, Hecht F, Koler RD, Linman JW. Clonal evolution in atypical chronic granulocytic leukemia: A non-Philadelphia translocation. Blood. 1978;51(6):997-1004.
    Bagby, G. C. ; Kaiser-McCaw, B. ; Hecht, F. ; Koler, R. D. ; Linman, J. W. / Clonal evolution in atypical chronic granulocytic leukemia : A non-Philadelphia translocation. In: Blood. 1978 ; Vol. 51, No. 6. pp. 997-1004.
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    AU - Hecht, F.

    AU - Koler, R. D.

    AU - Linman, J. W.

    PY - 1978

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    N2 - Hemopoietic cells in chronic granulocytic leukemia (CGL) frequently contain a chromosome translocation involving chromosome 22 and another autosome, usually number 9. The translocated chromosome 22 is known as the Philadelphia (Ph) chromosome. The appearance of a second Ph chromosome is the most common cytogenetic abnormality in CGL signaling the blastic phase. For 6 yr we serially studied a man with atypical CGL whose marrow cells were marked by a translocation from chromosome 18 to chromosome 11 [46XY, t(11;18) (q23;q12)]. Three months prior to blast transformation there appeared an extra copy of the marker chromosome 18: 47XY,t(11;18) (q23;q12), + (18p11 →18q12). This man presents a new cytogenetic pattern of clonal evolution in CGL. The pattern is analogous to that of the Ph chromosome and is characterized by a balanced chromosomal rearrangement and the subsequent acquisition of an extra copy of the small translocation chromosome immediately prior to blast transformation.

    AB - Hemopoietic cells in chronic granulocytic leukemia (CGL) frequently contain a chromosome translocation involving chromosome 22 and another autosome, usually number 9. The translocated chromosome 22 is known as the Philadelphia (Ph) chromosome. The appearance of a second Ph chromosome is the most common cytogenetic abnormality in CGL signaling the blastic phase. For 6 yr we serially studied a man with atypical CGL whose marrow cells were marked by a translocation from chromosome 18 to chromosome 11 [46XY, t(11;18) (q23;q12)]. Three months prior to blast transformation there appeared an extra copy of the marker chromosome 18: 47XY,t(11;18) (q23;q12), + (18p11 →18q12). This man presents a new cytogenetic pattern of clonal evolution in CGL. The pattern is analogous to that of the Ph chromosome and is characterized by a balanced chromosomal rearrangement and the subsequent acquisition of an extra copy of the small translocation chromosome immediately prior to blast transformation.

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