Clonal enrichments of Vδ2-γδ T cells in Mycobacterium tuberculosis-infected human lungs

Corinna A. Kulicke, Deborah A. Lewinsohn, David M. Lewinsohn

Research output: Contribution to journalReview article

Abstract

Unconventional T cell subsets, including donor-unrestricted T cells (DURTs) and γδ T cells, are promising new players in the treatment and prevention of infectious diseases. In this issue of the JCI, Ogongo et al. used T cell receptor (TCR) sequencing to characterize unconventional T cell subsets in surgical lung resections and blood from Mycobacterium tuberculosis-infected (Mtb-infected) individuals with and without HIV coinfection. The study revealed highly localized expansions of γδ T cell clonotypes not previously associated with the immune response to Mtb and demonstrates the power of high-throughput analysis of the TCR repertoire directly from infected tissue. The findings contribute to our understanding of tuberculosis control and have implications for the development of both therapeutic and vaccination strategies.

Original languageEnglish (US)
Pages (from-to)68-70
Number of pages3
JournalJournal of Clinical Investigation
Volume130
Issue number1
DOIs
StatePublished - Jan 2 2020

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Mycobacterium tuberculosis
T-Lymphocyte Subsets
T-Cell Antigen Receptor
T-Lymphocytes
Lung
Coinfection
Communicable Diseases
Vaccination
Tuberculosis
HIV
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clonal enrichments of Vδ2-γδ T cells in Mycobacterium tuberculosis-infected human lungs. / Kulicke, Corinna A.; Lewinsohn, Deborah A.; Lewinsohn, David M.

In: Journal of Clinical Investigation, Vol. 130, No. 1, 02.01.2020, p. 68-70.

Research output: Contribution to journalReview article

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