Clinical trial of a formal group fatigue program in multiple sclerosis

C. L. Hugos, L. F. Copperman, B. E. Fuller, V. Yadav, J. Lovera, D. N. Bourdette

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Fatigue: Take Control is a novel program to teach fatigue management to people with multiple sclerosis (MS) following recommendations in the Fatigue and Multiple Sclerosis guideline. Fatigue: Take Control includes six 2-hour group sessions with DVD viewing, discussion and homework and accompanying participant and leader workbooks. While many people have participated in Fatigue: Take Control programs, its efficacy has not been determined. The objective of this study was to determine whether participation in Fatigue: Take Control reduces fatigue and increases self-efficacy in people with MS. Thirty participants were randomly assigned to a group who immediately participated in the program (FTC) or a wait-list group (WL). The primary outcome was the Modified Fatigue Impact Scale (MFIS) and secondary outcomes were the Multiple Sclerosis Self-Efficacy Scale (MSSE) and the Fatigue Severity Scale (FSS). The MFIS was administered on 10 occasions. Other measures were administered on four occasions. A mixed model tested the effects using all observations. Compared with the WL, the FTC group had significantly more improvement on the MFIS [F(1, 269) = 7.079, p = 0.008] and the MSSE [F(1, 111) = 5.636, p = 0.019]. No significant effect was found for the FSS. Across all visits, fatigue was significantly lower and self-efficacy was significantly higher for the FTC group compared with the WL group. This pilot study demonstrated significant effects in fatigue and self-efficacy among subjects taking the Fatigue: Take Control program, suggesting that this comprehensive program based on the Fatigue and Multiple Sclerosis guideline may be beneficial in MS.

Original languageEnglish (US)
Pages (from-to)724-732
Number of pages9
JournalMultiple Sclerosis
Issue number6
StatePublished - Jun 2010


  • Energy conservation
  • Exercise
  • Fatigue
  • Guideline
  • Multiple sclerosis
  • Quality of life
  • Rehabilitation
  • Self-efficacy
  • Symptom management

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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