Clinical effects of a combination treatment with cefodizime and minocycline for infections in patients complicated with hematological disorders

K. Hirakawa, S. Tsuda, S. Misawa, Y. Kuzuyama, Hiroyuki Nakai, T. Seriu, T. Takashima, S. Tanaka, H. Nishigaki, S. Yokota, S. Horiike, M. Taniwaki, K. Kashima, H. Nakagawa, H. Fujii, T. Nakai, Y. Ohkawara

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Abstract

We evaluated clinical effects and toxicities of a combination in treatment with cefodizime (CDZM) and minocycline (MINO) for infections complicated with hematological disorders in 67 patients. Fifty-nine patients were evaluable, including 32 with acute leukemia, 15 with malignant lymphoma, and 12 with other hematological disorders. Clinical efficacies were excellent in 17 cases, good in 24 cases, fair in 2 cases, and poor in 16 cases. The efficacy rate was 69.5% (41 cases/59 cases). This treatment was also effective in 8 of 12 cases in which granulocyte counts were less than 500/μl through the course of administration. No subjective side effects were observed. Abnormal values in laboratory tests were noted in 5 cases. Mild elevations of GOT, GPT, Al-P and bilirubin were observed, but none was serious. Thus, the combination of CDZM and MINO is an effective and safe regimen for the treatment of infections in patients complicated with hematological disorders.

Original languageEnglish (US)
Pages (from-to)686-696
Number of pages11
JournalJapanese Journal of Antibiotics
Volume46
Issue number8
StatePublished - 1993
Externally publishedYes

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Minocycline
Infection
Bilirubin
Granulocytes
Lymphoma
Leukemia
Therapeutics
cefodizime

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Clinical effects of a combination treatment with cefodizime and minocycline for infections in patients complicated with hematological disorders. / Hirakawa, K.; Tsuda, S.; Misawa, S.; Kuzuyama, Y.; Nakai, Hiroyuki; Seriu, T.; Takashima, T.; Tanaka, S.; Nishigaki, H.; Yokota, S.; Horiike, S.; Taniwaki, M.; Kashima, K.; Nakagawa, H.; Fujii, H.; Nakai, T.; Ohkawara, Y.

In: Japanese Journal of Antibiotics, Vol. 46, No. 8, 1993, p. 686-696.

Research output: Contribution to journalArticle

Hirakawa, K, Tsuda, S, Misawa, S, Kuzuyama, Y, Nakai, H, Seriu, T, Takashima, T, Tanaka, S, Nishigaki, H, Yokota, S, Horiike, S, Taniwaki, M, Kashima, K, Nakagawa, H, Fujii, H, Nakai, T & Ohkawara, Y 1993, 'Clinical effects of a combination treatment with cefodizime and minocycline for infections in patients complicated with hematological disorders', Japanese Journal of Antibiotics, vol. 46, no. 8, pp. 686-696.
Hirakawa, K. ; Tsuda, S. ; Misawa, S. ; Kuzuyama, Y. ; Nakai, Hiroyuki ; Seriu, T. ; Takashima, T. ; Tanaka, S. ; Nishigaki, H. ; Yokota, S. ; Horiike, S. ; Taniwaki, M. ; Kashima, K. ; Nakagawa, H. ; Fujii, H. ; Nakai, T. ; Ohkawara, Y. / Clinical effects of a combination treatment with cefodizime and minocycline for infections in patients complicated with hematological disorders. In: Japanese Journal of Antibiotics. 1993 ; Vol. 46, No. 8. pp. 686-696.
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AU - Hirakawa, K.

AU - Tsuda, S.

AU - Misawa, S.

AU - Kuzuyama, Y.

AU - Nakai, Hiroyuki

AU - Seriu, T.

AU - Takashima, T.

AU - Tanaka, S.

AU - Nishigaki, H.

AU - Yokota, S.

AU - Horiike, S.

AU - Taniwaki, M.

AU - Kashima, K.

AU - Nakagawa, H.

AU - Fujii, H.

AU - Nakai, T.

AU - Ohkawara, Y.

PY - 1993

Y1 - 1993

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