TY - JOUR
T1 - Clear cell odontogenic carcinoma
T2 - Report of a case and analysis of the literature
AU - Brandwein, Margaret
AU - Said-Al-Naief, Nasser
AU - Gordon, Ron
AU - Urken, Mark
PY - 2002/9
Y1 - 2002/9
N2 - Background: Clear cell odontogenic carcinoma (CCOC), which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases. Objectives: To report the clinicopathologic findings and follow-up of a case of CCOC and to review the literature. Design: Case report and literature review. Main Outcome Measurements: Findings from histologic analysis, immunohistochemistry, and electron microscopy. Results: An 81-year-old woman experienced 3 locoregional recurrences within 21 months of initial therapy. She is presently disease free, 4.5 years after initial resection, having received multiple resections and adjuvant radiotherapy. Conclusions: The diagnosis of CCOC must be considered in the differential diagnosis of jaw tumors with a clear cell component. For these tumors, resection with negative margins is the treatment of choice because more conservative surgery (eg, curettage) inevitably results in recurrence and/or metastasis. Adjuvant radiotherapy is a rational option for tumors that have eroded cortex.
AB - Background: Clear cell odontogenic carcinoma (CCOC), which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases. Objectives: To report the clinicopathologic findings and follow-up of a case of CCOC and to review the literature. Design: Case report and literature review. Main Outcome Measurements: Findings from histologic analysis, immunohistochemistry, and electron microscopy. Results: An 81-year-old woman experienced 3 locoregional recurrences within 21 months of initial therapy. She is presently disease free, 4.5 years after initial resection, having received multiple resections and adjuvant radiotherapy. Conclusions: The diagnosis of CCOC must be considered in the differential diagnosis of jaw tumors with a clear cell component. For these tumors, resection with negative margins is the treatment of choice because more conservative surgery (eg, curettage) inevitably results in recurrence and/or metastasis. Adjuvant radiotherapy is a rational option for tumors that have eroded cortex.
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U2 - 10.1001/archotol.128.9.1089
DO - 10.1001/archotol.128.9.1089
M3 - Article
C2 - 12220218
AN - SCOPUS:0036712490
SN - 0886-4470
VL - 128
SP - 1089
EP - 1095
JO - Archives of Otolaryngology - Head and Neck Surgery
JF - Archives of Otolaryngology - Head and Neck Surgery
IS - 9
ER -