CKD, plasma lipids, and common carotid intima-media thickness: Results from the multi-ethnic study of atherosclerosis

Julio A. Lamprea-Montealegre, Brad C. Astor, Robin L. McClelland, Ian H. de Boer, Gregory L. Burke, Christopher Sibley, Daniel O'Leary, A. Richey Sharrett, Moyses Szklo

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20 Scopus citations

Abstract

Background and objectives Altered levels of atherogenic lipoproteins have been shown to be common in mild kidney dysfunction. This study sought to determine the associations between plasma lipids (including LDL particle distribution) and subclinical atherosclerosis measured by the common carotid intima-media thickness (IMT) across levels of estimated GFR (eGFR) and to assess whether inflammation modifies these associations. Design, setting, participants, & measurements Cross-sectional analyses of 6572 participants in the Multi-Ethnic Study of Atherosclerosis enrolled from 2000 to 2002 were performed. Results CKD, defined as eGFR 2, was present in 853 individuals (13.0%). Associations of total cholesterol and LDL cholesterol (LDL-C) with IMT were J shaped, particularly among participants with CKD (P value for interaction, P=0.01). HDL cholesterol (HDL-C) and small-dense LDL-C were consistently and linearly associated with IMT across levels of eGFR. The results showed differences in IMT of -21.41 (95% confidence interval, -41.00, -1.57) in eGFR ≥60 and -58.49 (-126.61, 9.63) in eGFR

Original languageEnglish (US)
Pages (from-to)1777-1785
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 7 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Lamprea-Montealegre, J. A., Astor, B. C., McClelland, R. L., de Boer, I. H., Burke, G. L., Sibley, C., ... Szklo, M. (2012). CKD, plasma lipids, and common carotid intima-media thickness: Results from the multi-ethnic study of atherosclerosis. Clinical Journal of the American Society of Nephrology, 7(11), 1777-1785. https://doi.org/10.2215/CJN.02090212