Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery

M. M. Swarbrick, I. T. Austrheim-Smith, K. L. Stanhope, M. D. Van Loan, M. R. Ali, Bruce Wolfe, P. J. Havel

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Abstract

Aims/hypothesis: In addition to weight loss, bariatric surgery for severe obesity dramatically alleviates insulin resistance. In this study, we investigated whether circulating concentrations of the high-molecular-weight (HMW) form of adiponectin are increased following gastric bypass surgery. The HMW form is implicated as the multimer responsible for adiponectin's hepatic insulin-sensitising actions. Subjects and methods: We studied 19 women who were undergoing Roux-en-Y gastric bypass surgery. Studies were conducted prior to, and 1 and 12 months after surgery. Results: One month after surgery, total plasma adiponectin concentrations were unchanged. Nevertheless, increases in both HMW (by 40±15%, p=0.006) and the proportion of adiponectin in the HMW form (from 40±2 to 50±2%, p

Original languageEnglish (US)
Pages (from-to)2552-2558
Number of pages7
JournalDiabetologia
Volume49
Issue number11
DOIs
Publication statusPublished - Nov 2006

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Keywords

  • Adiponectin
  • Clinical science
  • Gastric bypass
  • Human
  • Insulin sensitivity
  • Weight regulation

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Swarbrick, M. M., Austrheim-Smith, I. T., Stanhope, K. L., Van Loan, M. D., Ali, M. R., Wolfe, B., & Havel, P. J. (2006). Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery. Diabetologia, 49(11), 2552-2558. https://doi.org/10.1007/s00125-006-0452-8