Circadian gene variants influence sleep and the sleep electroencephalogram in humans

Anne Marie Chang, Andrew C. Bjonnes, Daniel Aeschbach, Orfeu M. Buxton, Joshua J. Gooley, Clare Anderson, Eliza Van Reen, Sean W. Cain, Charles A. Czeisler, Jeanne F. Duffy, Steven W. Lockley, Steven Shea, Frank A J L Scheer, Richa Saxena

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The sleep electroencephalogram (EEG) is highly heritable in humans and yet little is known about the genetic basis of inter-individual differences in sleep architecture. The aim of this study was to identify associations between candidate circadian gene variants and the polysomnogram, recorded under highly controlled laboratory conditions during a baseline, overnight, 8 h sleep opportunity. A candidate gene approach was employed to analyze single-nucleotide polymorphisms from five circadian-related genes in a two-phase analysis of 84 healthy young adults (28 F; 23.21 ± 2.97 years) of European ancestry. A common variant in Period2 (PER2) was associated with 20 min less slow-wave sleep (SWS) in carriers of the minor allele than in noncarriers, representing a 22% reduction in SWS duration. Moreover, spectral analysis in a subset of participants (n = 37) showed the same PER2 polymorphism was associated with reduced EEG power density in the low delta range (0.25–1.0 Hz) during non-REM sleep and lower slow-wave activity (0.75–4.5 Hz) in the early part of the sleep episode. These results indicate the involvement of PER2 in the homeostatic process of sleep. Additionally, a rare variant in Melatonin Receptor 1B was associated with longer REM sleep latency, with minor allele carriers exhibiting an average of 65 min (87%) longer latency from sleep onset to REM sleep, compared to noncarriers. These findings suggest that circadian-related genes can modulate sleep architecture and the sleep EEG, including specific parameters previously implicated in the homeostatic regulation of sleep.

Original languageEnglish (US)
Pages (from-to)561-573
Number of pages13
JournalChronobiology International
Volume33
Issue number5
DOIs
StatePublished - May 27 2016

Fingerprint

Electroencephalography
Sleep
Genes
REM Sleep
Melatonin MT2 Receptor
Alleles
Individuality
Single Nucleotide Polymorphism
Young Adult

Keywords

  • Circadian genes
  • sleep EEG
  • slow-wave activity
  • slow-wave sleep

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Chang, A. M., Bjonnes, A. C., Aeschbach, D., Buxton, O. M., Gooley, J. J., Anderson, C., ... Saxena, R. (2016). Circadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiology International, 33(5), 561-573. https://doi.org/10.3109/07420528.2016.1167078

Circadian gene variants influence sleep and the sleep electroencephalogram in humans. / Chang, Anne Marie; Bjonnes, Andrew C.; Aeschbach, Daniel; Buxton, Orfeu M.; Gooley, Joshua J.; Anderson, Clare; Van Reen, Eliza; Cain, Sean W.; Czeisler, Charles A.; Duffy, Jeanne F.; Lockley, Steven W.; Shea, Steven; Scheer, Frank A J L; Saxena, Richa.

In: Chronobiology International, Vol. 33, No. 5, 27.05.2016, p. 561-573.

Research output: Contribution to journalArticle

Chang, AM, Bjonnes, AC, Aeschbach, D, Buxton, OM, Gooley, JJ, Anderson, C, Van Reen, E, Cain, SW, Czeisler, CA, Duffy, JF, Lockley, SW, Shea, S, Scheer, FAJL & Saxena, R 2016, 'Circadian gene variants influence sleep and the sleep electroencephalogram in humans', Chronobiology International, vol. 33, no. 5, pp. 561-573. https://doi.org/10.3109/07420528.2016.1167078
Chang AM, Bjonnes AC, Aeschbach D, Buxton OM, Gooley JJ, Anderson C et al. Circadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiology International. 2016 May 27;33(5):561-573. https://doi.org/10.3109/07420528.2016.1167078
Chang, Anne Marie ; Bjonnes, Andrew C. ; Aeschbach, Daniel ; Buxton, Orfeu M. ; Gooley, Joshua J. ; Anderson, Clare ; Van Reen, Eliza ; Cain, Sean W. ; Czeisler, Charles A. ; Duffy, Jeanne F. ; Lockley, Steven W. ; Shea, Steven ; Scheer, Frank A J L ; Saxena, Richa. / Circadian gene variants influence sleep and the sleep electroencephalogram in humans. In: Chronobiology International. 2016 ; Vol. 33, No. 5. pp. 561-573.
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