TY - JOUR
T1 - Ciliary Body and Choroidal Melanomas Treated by Proton Beam Irradiation
T2 - Histopathologic Study of Eyes
AU - Seddon, Johanna M.
AU - Gragoudas, Evangelos S.
AU - Albert, Daniel M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1983/9
Y1 - 1983/9
N2 - Proton beam irradiation resulted in clinical and/or histopathological regression of large ciliary body and choroidal melanomas in three eyes. Enucleations were performed 6½ weeks, five months, and 11 months after irradiation for angleclosure glaucoma from total retinal detachment, increase in retinal detachment, and neovascular glaucoma, respectively. A direct relationship was found between the length of the interval from irradiation to enucleation and the degree of histologic changes. Vascular changes in the tumors included endothelial cell swelling and decreased lumen size, basement membrane thickening, collapse of sinusoidal vessels, and thrombosis of vessels. Although apparently unaltered tumor cells remained, degenerative changes occurred in some melanoma cells, including lipid vacuoles in cytoplasm, pyknotic nuclei, and balloon cell formation. Patchy areas of necrosis and proteinaceous exudate were present. Pigment-laden macrophages were found near tumor vessels and all had a substantial chronic inflammatory infiltrate. The effect of proton beam irradiation on tumor vessels probably plays an important role in uveal melanoma regression.
AB - Proton beam irradiation resulted in clinical and/or histopathological regression of large ciliary body and choroidal melanomas in three eyes. Enucleations were performed 6½ weeks, five months, and 11 months after irradiation for angleclosure glaucoma from total retinal detachment, increase in retinal detachment, and neovascular glaucoma, respectively. A direct relationship was found between the length of the interval from irradiation to enucleation and the degree of histologic changes. Vascular changes in the tumors included endothelial cell swelling and decreased lumen size, basement membrane thickening, collapse of sinusoidal vessels, and thrombosis of vessels. Although apparently unaltered tumor cells remained, degenerative changes occurred in some melanoma cells, including lipid vacuoles in cytoplasm, pyknotic nuclei, and balloon cell formation. Patchy areas of necrosis and proteinaceous exudate were present. Pigment-laden macrophages were found near tumor vessels and all had a substantial chronic inflammatory infiltrate. The effect of proton beam irradiation on tumor vessels probably plays an important role in uveal melanoma regression.
UR - http://www.scopus.com/inward/record.url?scp=0020507471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020507471&partnerID=8YFLogxK
U2 - 10.1001/archopht.1983.01040020404014
DO - 10.1001/archopht.1983.01040020404014
M3 - Article
C2 - 6311146
AN - SCOPUS:0020507471
SN - 0003-9950
VL - 101
SP - 1402
EP - 1408
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 9
ER -