Ciliary Body and Choroidal Melanomas Treated by Proton Beam Irradiation: Histopathologic Study of Eyes

Johanna M. Seddon, Evangelos S. Gragoudas, Daniel Albert

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Proton beam irradiation resulted in clinical and/or histopathological regression of large ciliary body and choroidal melanomas in three eyes. Enucleations were performed 6½ weeks, five months, and 11 months after irradiation for angleclosure glaucoma from total retinal detachment, increase in retinal detachment, and neovascular glaucoma, respectively. A direct relationship was found between the length of the interval from irradiation to enucleation and the degree of histologic changes. Vascular changes in the tumors included endothelial cell swelling and decreased lumen size, basement membrane thickening, collapse of sinusoidal vessels, and thrombosis of vessels. Although apparently unaltered tumor cells remained, degenerative changes occurred in some melanoma cells, including lipid vacuoles in cytoplasm, pyknotic nuclei, and balloon cell formation. Patchy areas of necrosis and proteinaceous exudate were present. Pigment-laden macrophages were found near tumor vessels and all had a substantial chronic inflammatory infiltrate. The effect of proton beam irradiation on tumor vessels probably plays an important role in uveal melanoma regression.

Original languageEnglish (US)
Pages (from-to)1402-1408
Number of pages7
JournalArchives of ophthalmology
Volume101
Issue number9
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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Ciliary Body
Protons
Melanoma
Retinal Detachment
Neoplasms
Neovascular Glaucoma
Exudates and Transudates
Vacuoles
Cell Nucleus
Basement Membrane
Glaucoma
Blood Vessels
Cytoplasm
Thrombosis
Necrosis
Endothelial Cells
Macrophages
Lipids

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ciliary Body and Choroidal Melanomas Treated by Proton Beam Irradiation : Histopathologic Study of Eyes. / Seddon, Johanna M.; Gragoudas, Evangelos S.; Albert, Daniel.

In: Archives of ophthalmology, Vol. 101, No. 9, 01.01.1983, p. 1402-1408.

Research output: Contribution to journalArticle

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