Chronic ulcerative herpes simplex virus infection of the vulva

Kelly Griffith-Bauer; Mary O'Hearn; Benjamin D. Ehst

doi:10.1159/000342953

Chronic ulcerative herpes simplex virus infection of the vulva

Kelly Griffith-Bauer, Mary O'Hearn, Benjamin D. Ehst

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Herpes simplex virus infections in HIV-infected individuals can be clinically unusual and difficult to treat due to underlying problems with cell-mediated immunity and the occurrence of antiviral resistance. Additionally, partial or incomplete restoration of immune function may result in chronic ulcerations that require rotational treatments. In this report, we describe the case of a 38-year-old HIV-positive woman who developed the ulcerative form of chronic herpes simplex infection despite highly active antiretroviral therapy and valacyclovir prophylaxis. Repeated intravenous courses of foscarnet and topical cidofovir finally controlled her erosions as her cell-mediated immunity was slowly restored.

Original language	English (US)
Pages (from-to)	192-196
Number of pages	5
Journal	Case Reports in Dermatology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1159/000342953
State	Published - Apr 20 2012
Externally published	Yes

Keywords

Chronic herpes simplex virus
HIV
Immune reconstitution inflammatory syndrome

ASJC Scopus subject areas

Dermatology

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10.1159/000342953

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title = "Chronic ulcerative herpes simplex virus infection of the vulva",

abstract = "Herpes simplex virus infections in HIV-infected individuals can be clinically unusual and difficult to treat due to underlying problems with cell-mediated immunity and the occurrence of antiviral resistance. Additionally, partial or incomplete restoration of immune function may result in chronic ulcerations that require rotational treatments. In this report, we describe the case of a 38-year-old HIV-positive woman who developed the ulcerative form of chronic herpes simplex infection despite highly active antiretroviral therapy and valacyclovir prophylaxis. Repeated intravenous courses of foscarnet and topical cidofovir finally controlled her erosions as her cell-mediated immunity was slowly restored.",

keywords = "Chronic herpes simplex virus, HIV, Immune reconstitution inflammatory syndrome",

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T1 - Chronic ulcerative herpes simplex virus infection of the vulva

AU - Griffith-Bauer, Kelly

AU - O'Hearn, Mary

AU - Ehst, Benjamin D.

PY - 2012/4/20

Y1 - 2012/4/20

N2 - Herpes simplex virus infections in HIV-infected individuals can be clinically unusual and difficult to treat due to underlying problems with cell-mediated immunity and the occurrence of antiviral resistance. Additionally, partial or incomplete restoration of immune function may result in chronic ulcerations that require rotational treatments. In this report, we describe the case of a 38-year-old HIV-positive woman who developed the ulcerative form of chronic herpes simplex infection despite highly active antiretroviral therapy and valacyclovir prophylaxis. Repeated intravenous courses of foscarnet and topical cidofovir finally controlled her erosions as her cell-mediated immunity was slowly restored.

AB - Herpes simplex virus infections in HIV-infected individuals can be clinically unusual and difficult to treat due to underlying problems with cell-mediated immunity and the occurrence of antiviral resistance. Additionally, partial or incomplete restoration of immune function may result in chronic ulcerations that require rotational treatments. In this report, we describe the case of a 38-year-old HIV-positive woman who developed the ulcerative form of chronic herpes simplex infection despite highly active antiretroviral therapy and valacyclovir prophylaxis. Repeated intravenous courses of foscarnet and topical cidofovir finally controlled her erosions as her cell-mediated immunity was slowly restored.

KW - Chronic herpes simplex virus

KW - HIV

KW - Immune reconstitution inflammatory syndrome

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Chronic ulcerative herpes simplex virus infection of the vulva

Abstract

Keywords

ASJC Scopus subject areas

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