Chronic ulcerative herpes simplex virus infection of the vulva

Kelly Griffith-Bauer, Mary O'Hearn, Benjamin D. Ehst

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Herpes simplex virus infections in HIV-infected individuals can be clinically unusual and difficult to treat due to underlying problems with cell-mediated immunity and the occurrence of antiviral resistance. Additionally, partial or incomplete restoration of immune function may result in chronic ulcerations that require rotational treatments. In this report, we describe the case of a 38-year-old HIV-positive woman who developed the ulcerative form of chronic herpes simplex infection despite highly active antiretroviral therapy and valacyclovir prophylaxis. Repeated intravenous courses of foscarnet and topical cidofovir finally controlled her erosions as her cell-mediated immunity was slowly restored. This case highlights the challenges that still exist in diagnosing and managing this rare presentation of herpes simplex virus

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalCase Reports in Dermatology
Volume4
Issue number3
DOIs
StatePublished - Apr 20 2012

Keywords

  • Chronic herpes simplex virus
  • HIV
  • Immune reconstitution inflammatory syndrome

ASJC Scopus subject areas

  • Dermatology

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