Chronic triiodothyronine supplementation does not improve the lipoprotein disorders of mildly uremic rats

B. Lacour, Jean-Baptiste Roullet, Y. Ricordel, T. Drueke

Research output: Contribution to journalArticle

Abstract

The present study was performed to appreciate the potential role that thyroid deficiency could play in the energy homeostasis and lipid metabolism of experimental chronic renal failure. For this purpose, 12 uremic rats that were supplemented with T3 (0.4 μg/100 g body weight/day) during 5 weeks by means of osmotically driven minipumps were compared to 12 unsupplemented uremic rats and 12 control rats. The chronic supplementation of uremic rats with T3 induced no significant change in body weight gain or in the serum concentration of insulin, glucose, glycerol, nonesterified fatty acids, total triglycerides (TG), total cholesterol, and total choline phospholipids. Similarly, the metabolism of TG-rich lipoproteins was not affected by the supplementation with T3 in these uremic rats as appreciated by TG production or TG degradation (adipose tissue lipoprotein lipase activity). T3 administration induced a significant decrease in serum β-hydroxybutyrate concentration and an increase in serum lactate concentration. Furthermore, heparin-releasable hepatic TG lipase activity as expressed per total liver mass was decreased in uremic rats treated with T3. The latter changes were observed in the absence of modifications of serum glucose or TG concentration. We conclude from these observations that rats with a moderate degree of chronic uremic do not seem to have a cellular thyroid deficiency sufficient to disturb their energy or lipid metabolism.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalNephron
Volume45
Issue number2
StatePublished - 1987
Externally publishedYes

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Triiodothyronine
Lipoproteins
Triglycerides
Serum
Lipid Metabolism
Energy Metabolism
Thyroid Gland
Hydroxybutyrates
Glucose
Lipoprotein Lipase
Liver
Choline
Lipase
Nonesterified Fatty Acids
Chronic Kidney Failure
Weight Gain
Heparin
Adipose Tissue
Lactic Acid
Phospholipids

ASJC Scopus subject areas

  • Nephrology

Cite this

Lacour, B., Roullet, J-B., Ricordel, Y., & Drueke, T. (1987). Chronic triiodothyronine supplementation does not improve the lipoprotein disorders of mildly uremic rats. Nephron, 45(2), 129-134.

Chronic triiodothyronine supplementation does not improve the lipoprotein disorders of mildly uremic rats. / Lacour, B.; Roullet, Jean-Baptiste; Ricordel, Y.; Drueke, T.

In: Nephron, Vol. 45, No. 2, 1987, p. 129-134.

Research output: Contribution to journalArticle

Lacour, B, Roullet, J-B, Ricordel, Y & Drueke, T 1987, 'Chronic triiodothyronine supplementation does not improve the lipoprotein disorders of mildly uremic rats', Nephron, vol. 45, no. 2, pp. 129-134.
Lacour, B. ; Roullet, Jean-Baptiste ; Ricordel, Y. ; Drueke, T. / Chronic triiodothyronine supplementation does not improve the lipoprotein disorders of mildly uremic rats. In: Nephron. 1987 ; Vol. 45, No. 2. pp. 129-134.
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