Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities

Aliye Uc; Dana K. Andersen; Melena D. Bellin; Jason I. Bruce; Asbjørn M. Drewes; John F. Engelhardt; Christopher E. Forsmark; Markus M. Lerch; Mark E. Lowe; Brent A. Neuschwander-Tetri; Stephen J. O'Keefe; Tonya M. Palermo; Pankaj Pasricha; Ashok K. Saluja; Vikesh K. Singh; Eva M. Szigethy; David C. Whitcomb; Dhiraj Yadav; Darwin L. Conwell

doi:10.1097/MPA.0000000000000713

Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities

Aliye Uc, Dana K. Andersen, Melena D. Bellin, Jason I. Bruce, Asbjørn M. Drewes, John F. Engelhardt, Christopher E. Forsmark, Markus M. Lerch, Mark E. Lowe, Brent A. Neuschwander-Tetri, Stephen J. O'Keefe, Tonya M. Palermo, Pankaj Pasricha, Ashok K. Saluja, Vikesh K. Singh, Eva M. Szigethy, David C. Whitcomb, Dhiraj Yadav, Darwin L. Conwell

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in chronic pancreatitis (CP) and its sequelae. This conference marked the 20th year anniversary of the discovery of the cationic trypsinogen (PRSS1) gene mutation for hereditary pancreatitis. The event was held on July 27, 2016, and structured into 4 sessions: (1) pathophysiology, (2) exocrine complications, (3) endocrine complications, and (4) pain. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to design better tools to diagnose CP and its sequelae early and reliably, identify predisposing risk factors for disease progression, develop standardized protocols to distinguish type 3c diabetes mellitus from other types of diabetes, and design effective therapeutic strategies through novel cell culture technologies, animal models mimicking human disease, and pain management tools. Gene therapy and cystic fibrosis conductance regulator potentiators as possible treatments of CP were discussed. Importantly, the need for CP end points and intermediate targets for future drug trials was emphasized.

Original language	English (US)
Pages (from-to)	1365-1375
Number of pages	11
Journal	Pancreas
Volume	45
Issue number	10
DOIs	https://doi.org/10.1097/MPA.0000000000000713
State	Published - Nov 1 2016

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

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Uc, A., Andersen, D. K., Bellin, M. D., Bruce, J. I., Drewes, A. M., Engelhardt, J. F., Forsmark, C. E., Lerch, M. M., Lowe, M. E., Neuschwander-Tetri, B. A., O'Keefe, S. J., Palermo, T. M., Pasricha, P., Saluja, A. K., Singh, V. K., Szigethy, E. M., Whitcomb, D. C., Yadav, D., & Conwell, D. L. (2016). Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities. Pancreas, 45(10), 1365-1375. https://doi.org/10.1097/MPA.0000000000000713

Uc, A, Andersen, DK, Bellin, MD, Bruce, JI, Drewes, AM, Engelhardt, JF, Forsmark, CE, Lerch, MM, Lowe, ME, Neuschwander-Tetri, BA, O'Keefe, SJ, Palermo, TM, Pasricha, P, Saluja, AK, Singh, VK, Szigethy, EM, Whitcomb, DC, Yadav, D & Conwell, DL 2016, 'Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities', Pancreas, vol. 45, no. 10, pp. 1365-1375. https://doi.org/10.1097/MPA.0000000000000713

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title = "Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities",

abstract = "A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in chronic pancreatitis (CP) and its sequelae. This conference marked the 20th year anniversary of the discovery of the cationic trypsinogen (PRSS1) gene mutation for hereditary pancreatitis. The event was held on July 27, 2016, and structured into 4 sessions: (1) pathophysiology, (2) exocrine complications, (3) endocrine complications, and (4) pain. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to design better tools to diagnose CP and its sequelae early and reliably, identify predisposing risk factors for disease progression, develop standardized protocols to distinguish type 3c diabetes mellitus from other types of diabetes, and design effective therapeutic strategies through novel cell culture technologies, animal models mimicking human disease, and pain management tools. Gene therapy and cystic fibrosis conductance regulator potentiators as possible treatments of CP were discussed. Importantly, the need for CP end points and intermediate targets for future drug trials was emphasized.",

author = "Aliye Uc and Andersen, {Dana K.} and Bellin, {Melena D.} and Bruce, {Jason I.} and Drewes, {Asbj{\o}rn M.} and Engelhardt, {John F.} and Forsmark, {Christopher E.} and Lerch, {Markus M.} and Lowe, {Mark E.} and Neuschwander-Tetri, {Brent A.} and O'Keefe, {Stephen J.} and Palermo, {Tonya M.} and Pankaj Pasricha and Saluja, {Ashok K.} and Singh, {Vikesh K.} and Szigethy, {Eva M.} and Whitcomb, {David C.} and Dhiraj Yadav and Conwell, {Darwin L.}",

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AU - Drewes, Asbjørn M.

AU - Engelhardt, John F.

AU - Forsmark, Christopher E.

AU - Lerch, Markus M.

AU - Lowe, Mark E.

AU - Neuschwander-Tetri, Brent A.

AU - O'Keefe, Stephen J.

AU - Palermo, Tonya M.

AU - Pasricha, Pankaj

AU - Saluja, Ashok K.

AU - Singh, Vikesh K.

AU - Szigethy, Eva M.

AU - Whitcomb, David C.

AU - Yadav, Dhiraj

AU - Conwell, Darwin L.

PY - 2016/11/1

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Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities

Abstract

ASJC Scopus subject areas

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