Chronic low-dose antiprogestin impairs preimplantation embryogenesis, but not oocyte nuclear maturation or fertilization in rhesus monkeys

Sherri M. Borman, Kristof Chwalisz, Richard Stouffer, Mary Zelinski

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Continual administration of low doses of the antiprogestin ZK137316 permits ovarian/menstrual cyclicity, but prevents pregnancy in female rhesus monkeys. The sites of contraceptive action remain unknown. This study determined whether chronic, low-dose antiprogestin exposure during follicular development impairs oocyte maturation in vivo, as well as fertilization and preimplantation embryogenesis in vitro. Adult, female rhesus monkeys exhibiting normal menstrual cycles received vehicle (n=9) or 0.03mg ZK137316 (n=8)/kg body weight i.m. daily for 3 months. Controlled ovarian stimulation with recombinant gonadotropins was initiated in the 3rd month. Oocytes collected from preovulatory follicles were evaluated for nuclear maturity and inseminated in vitro. Preimplantation embryonic development was monitored in vitro. The total number of oocytes and percentage collected at each nuclear stage were similar in both groups. More (P

    Original languageEnglish (US)
    Pages (from-to)1041-1051
    Number of pages11
    JournalSteroids
    Volume68
    Issue number10-13
    DOIs
    StatePublished - Nov 2003

    Fingerprint

    Contraceptive Agents
    Macaca mulatta
    Gonadotropins
    Fertilization
    Oocytes
    Embryonic Development
    Ovulation Induction
    Periodicity
    Menstrual Cycle
    Body Weight
    Pregnancy
    In Vitro Techniques

    Keywords

    • Antiprogestin
    • Contraception
    • Oocyte
    • Preimplantation embryogenesis

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Molecular Biology

    Cite this

    Chronic low-dose antiprogestin impairs preimplantation embryogenesis, but not oocyte nuclear maturation or fertilization in rhesus monkeys. / Borman, Sherri M.; Chwalisz, Kristof; Stouffer, Richard; Zelinski, Mary.

    In: Steroids, Vol. 68, No. 10-13, 11.2003, p. 1041-1051.

    Research output: Contribution to journalArticle

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    AU - Zelinski, Mary

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