Chromosomal reassignment: Yacs containing both yes1 and thymidylate synthase map to the short arm of chromosome 18

Gary A. Silverman, Wen Lin Kuo, Patricia Taillon-Miller, Joe W. Gray

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The YES1 proto-oncogene was mapped previously to human chromosome band 18q21.3 by using isotopic in situ hybridization. Using yeast artificial chromosomes (YACs) as probes and fluorescence in situ hybridization, a strong signal was detected in the region corresponding to 18p11.3. Restriction digests confirmed that the YACs contained the YES1 gene and not other cross-hybridizing, protein-tyrosine kinases. In addition, these-YACs were found to contain another 18p11.32 gene, thymidlylate synthase. These genes were less than 50 kb apart. Collectively, these data suggest that YES1 maps to 18p11.32 rather than to 18q21.3.

Original languageEnglish (US)
Pages (from-to)442-445
Number of pages4
JournalGenomics
Volume15
Issue number2
DOIs
StatePublished - Feb 1993

ASJC Scopus subject areas

  • Genetics

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