TY - JOUR
T1 - Chromosomal reassignment
T2 - Yacs containing both yes1 and thymidylate synthase map to the short arm of chromosome 18
AU - Silverman, Gary A.
AU - Kuo, Wen Lin
AU - Taillon-Miller, Patricia
AU - Gray, Joe W.
PY - 1993/2
Y1 - 1993/2
N2 - The YES1 proto-oncogene was mapped previously to human chromosome band 18q21.3 by using isotopic in situ hybridization. Using yeast artificial chromosomes (YACs) as probes and fluorescence in situ hybridization, a strong signal was detected in the region corresponding to 18p11.3. Restriction digests confirmed that the YACs contained the YES1 gene and not other cross-hybridizing, protein-tyrosine kinases. In addition, these-YACs were found to contain another 18p11.32 gene, thymidlylate synthase. These genes were less than 50 kb apart. Collectively, these data suggest that YES1 maps to 18p11.32 rather than to 18q21.3.
AB - The YES1 proto-oncogene was mapped previously to human chromosome band 18q21.3 by using isotopic in situ hybridization. Using yeast artificial chromosomes (YACs) as probes and fluorescence in situ hybridization, a strong signal was detected in the region corresponding to 18p11.3. Restriction digests confirmed that the YACs contained the YES1 gene and not other cross-hybridizing, protein-tyrosine kinases. In addition, these-YACs were found to contain another 18p11.32 gene, thymidlylate synthase. These genes were less than 50 kb apart. Collectively, these data suggest that YES1 maps to 18p11.32 rather than to 18q21.3.
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U2 - 10.1006/geno.1993.1086
DO - 10.1006/geno.1993.1086
M3 - Article
C2 - 8449516
AN - SCOPUS:0027480851
SN - 0888-7543
VL - 15
SP - 442
EP - 445
JO - Genomics
JF - Genomics
IS - 2
ER -