Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma

Itziar Salaverria, Andreas Zettl, Silvia Beà, Elena M. Hartmann, Sandeep S. Dave, George W. Wright, Evert Jan Boerma, Philip M. Kluin, German Ott, Wing C. Chan, Dennis D. Weisenburger, Armando Lopez-Guillermo, Randy D. Gascoyne, Jan Delabie, Lisa M. Rimsza, Rita Braziel, Elaine S. Jaffe, Louis M. Staudt, Hans Konrad Müller-Hermelink, Elias CampoAndreas Rosenwald

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Abstract

Background: Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt's lymphoma nonetheless show a molecular signature of Burkitt's lymphoma ('discrepant Burkitt's lymphoma'). Given the different treatment of Burkitt's lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt's lymphoma. Design and Methods: We studied tumors from 51 Burkitt's lymphoma patients, comprising 26 with classic Burkitt's lymphoma, 17 with atypical Burkitt's lymphoma and 8 with 'discrepant Burkitt's lymphoma', by comparative genomic hybridization and gene expression profiling. Results: Classic and atypical Burkitt's lymphoma (excluding 'discrepant Burkitt's lymphoma'), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. 'Discrepant Burkitt's lymphoma', however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt's lymphoma and from diffuse large B-cell lymphoma. Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. Conclusions: Pediatric and adult Burkitt's lymphoma are molecularly homogeneous, whereas 'discrepant Burkitt's lymphoma' differ in underlying genetic and clinical features from typical/atypical Burkitt's lymphoma. 'Discrepant Burkitt's lymphoma' may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy.

Original languageEnglish (US)
Pages (from-to)1327-1334
Number of pages8
JournalHaematologica
Volume93
Issue number9
DOIs
StatePublished - Sep 2008

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Comparative Genomic Hybridization
Burkitt Lymphoma
Gene Expression
B-Cell Lymphoma
Lymphoma, Large B-Cell, Diffuse
Gene Expression Profiling
Pediatrics

Keywords

  • Burkitt's lymphoma
  • Comparative genomic hybridization
  • DLBCL
  • Gene expression

ASJC Scopus subject areas

  • Hematology

Cite this

Salaverria, I., Zettl, A., Beà, S., Hartmann, E. M., Dave, S. S., Wright, G. W., ... Rosenwald, A. (2008). Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma. Haematologica, 93(9), 1327-1334. https://doi.org/10.3324/haematol.13071

Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma. / Salaverria, Itziar; Zettl, Andreas; Beà, Silvia; Hartmann, Elena M.; Dave, Sandeep S.; Wright, George W.; Boerma, Evert Jan; Kluin, Philip M.; Ott, German; Chan, Wing C.; Weisenburger, Dennis D.; Lopez-Guillermo, Armando; Gascoyne, Randy D.; Delabie, Jan; Rimsza, Lisa M.; Braziel, Rita; Jaffe, Elaine S.; Staudt, Louis M.; Müller-Hermelink, Hans Konrad; Campo, Elias; Rosenwald, Andreas.

In: Haematologica, Vol. 93, No. 9, 09.2008, p. 1327-1334.

Research output: Contribution to journalArticle

Salaverria, I, Zettl, A, Beà, S, Hartmann, EM, Dave, SS, Wright, GW, Boerma, EJ, Kluin, PM, Ott, G, Chan, WC, Weisenburger, DD, Lopez-Guillermo, A, Gascoyne, RD, Delabie, J, Rimsza, LM, Braziel, R, Jaffe, ES, Staudt, LM, Müller-Hermelink, HK, Campo, E & Rosenwald, A 2008, 'Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma', Haematologica, vol. 93, no. 9, pp. 1327-1334. https://doi.org/10.3324/haematol.13071
Salaverria, Itziar ; Zettl, Andreas ; Beà, Silvia ; Hartmann, Elena M. ; Dave, Sandeep S. ; Wright, George W. ; Boerma, Evert Jan ; Kluin, Philip M. ; Ott, German ; Chan, Wing C. ; Weisenburger, Dennis D. ; Lopez-Guillermo, Armando ; Gascoyne, Randy D. ; Delabie, Jan ; Rimsza, Lisa M. ; Braziel, Rita ; Jaffe, Elaine S. ; Staudt, Louis M. ; Müller-Hermelink, Hans Konrad ; Campo, Elias ; Rosenwald, Andreas. / Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma. In: Haematologica. 2008 ; Vol. 93, No. 9. pp. 1327-1334.
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abstract = "Background: Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt's lymphoma nonetheless show a molecular signature of Burkitt's lymphoma ('discrepant Burkitt's lymphoma'). Given the different treatment of Burkitt's lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt's lymphoma. Design and Methods: We studied tumors from 51 Burkitt's lymphoma patients, comprising 26 with classic Burkitt's lymphoma, 17 with atypical Burkitt's lymphoma and 8 with 'discrepant Burkitt's lymphoma', by comparative genomic hybridization and gene expression profiling. Results: Classic and atypical Burkitt's lymphoma (excluding 'discrepant Burkitt's lymphoma'), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. 'Discrepant Burkitt's lymphoma', however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt's lymphoma and from diffuse large B-cell lymphoma. Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. Conclusions: Pediatric and adult Burkitt's lymphoma are molecularly homogeneous, whereas 'discrepant Burkitt's lymphoma' differ in underlying genetic and clinical features from typical/atypical Burkitt's lymphoma. 'Discrepant Burkitt's lymphoma' may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy.",
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T1 - Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma

AU - Salaverria, Itziar

AU - Zettl, Andreas

AU - Beà, Silvia

AU - Hartmann, Elena M.

AU - Dave, Sandeep S.

AU - Wright, George W.

AU - Boerma, Evert Jan

AU - Kluin, Philip M.

AU - Ott, German

AU - Chan, Wing C.

AU - Weisenburger, Dennis D.

AU - Lopez-Guillermo, Armando

AU - Gascoyne, Randy D.

AU - Delabie, Jan

AU - Rimsza, Lisa M.

AU - Braziel, Rita

AU - Jaffe, Elaine S.

AU - Staudt, Louis M.

AU - Müller-Hermelink, Hans Konrad

AU - Campo, Elias

AU - Rosenwald, Andreas

PY - 2008/9

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N2 - Background: Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt's lymphoma nonetheless show a molecular signature of Burkitt's lymphoma ('discrepant Burkitt's lymphoma'). Given the different treatment of Burkitt's lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt's lymphoma. Design and Methods: We studied tumors from 51 Burkitt's lymphoma patients, comprising 26 with classic Burkitt's lymphoma, 17 with atypical Burkitt's lymphoma and 8 with 'discrepant Burkitt's lymphoma', by comparative genomic hybridization and gene expression profiling. Results: Classic and atypical Burkitt's lymphoma (excluding 'discrepant Burkitt's lymphoma'), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. 'Discrepant Burkitt's lymphoma', however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt's lymphoma and from diffuse large B-cell lymphoma. Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. Conclusions: Pediatric and adult Burkitt's lymphoma are molecularly homogeneous, whereas 'discrepant Burkitt's lymphoma' differ in underlying genetic and clinical features from typical/atypical Burkitt's lymphoma. 'Discrepant Burkitt's lymphoma' may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy.

AB - Background: Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt's lymphoma nonetheless show a molecular signature of Burkitt's lymphoma ('discrepant Burkitt's lymphoma'). Given the different treatment of Burkitt's lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt's lymphoma. Design and Methods: We studied tumors from 51 Burkitt's lymphoma patients, comprising 26 with classic Burkitt's lymphoma, 17 with atypical Burkitt's lymphoma and 8 with 'discrepant Burkitt's lymphoma', by comparative genomic hybridization and gene expression profiling. Results: Classic and atypical Burkitt's lymphoma (excluding 'discrepant Burkitt's lymphoma'), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. 'Discrepant Burkitt's lymphoma', however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt's lymphoma and from diffuse large B-cell lymphoma. Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. Conclusions: Pediatric and adult Burkitt's lymphoma are molecularly homogeneous, whereas 'discrepant Burkitt's lymphoma' differ in underlying genetic and clinical features from typical/atypical Burkitt's lymphoma. 'Discrepant Burkitt's lymphoma' may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy.

KW - Burkitt's lymphoma

KW - Comparative genomic hybridization

KW - DLBCL

KW - Gene expression

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