Chromatic visualization of reflectivity variance within hybridized directional OCT images

Vikram S. Makhijani, Austin Roorda, Jan Kristine Bayabo, Kevin K. Tong, Carlos A. Rivera-Carpio, Brandon J. Lujan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

This study presents a new method of visualizing hybridized images of retinal spectral domain optical coherence tomography (SDOCT) data comprised of varied directional reflectivity. Due to the varying reflectivity of certain retinal structures relative to angle of incident light, SDOCT images obtained with differing entry positions result in nonequivalent images of corresponding cellular and extracellular structures, especially within layers containing photoreceptor components. Harnessing this property, cross-sectional pathologic and non-pathologic macular images were obtained from multiple pupil entry positions using commercially-available OCT systems, and custom segmentation, alignment, and hybridization algorithms were developed to chromatically visualize the composite variance of reflectivity effects. In these images, strong relative reflectivity from any given direction visualizes as relative intensity of its corresponding color channel. Evident in non-pathologic images was marked enhancement of Henle?s fiber layer (HFL) visualization and varying reflectivity patterns of the inner limiting membrane (ILM) and photoreceptor inner/outer segment junctions (IS/OS). Pathologic images displayed similar and additional patterns. Such visualization may allow a more intuitive understanding of structural and physiologic processes in retinal pathologies.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
DOIs
StatePublished - May 22 2013
Externally publishedYes
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII - San Francisco, CA, United States
Duration: Feb 4 2013Feb 6 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8571
ISSN (Print)1605-7422

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
CountryUnited States
CitySan Francisco, CA
Period2/4/132/6/13

Keywords

  • Directional OCT
  • HFL
  • IS/OS
  • OCT
  • SDOCT
  • macula
  • retina
  • visualization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Chromatic visualization of reflectivity variance within hybridized directional OCT images'. Together they form a unique fingerprint.

  • Cite this

    Makhijani, V. S., Roorda, A., Bayabo, J. K., Tong, K. K., Rivera-Carpio, C. A., & Lujan, B. J. (2013). Chromatic visualization of reflectivity variance within hybridized directional OCT images. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII [857105] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8571). https://doi.org/10.1117/12.2007141