Chondromyxoid fibroma of the nasal cavity with an interstitial insertion between chromosomes 6 and 19

Cristina A. Smith, R. Ellen Magenis, Eleanor Himoe, Cheree Smith, Atiya Mansoor

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Chondromyxoid fibroma is an uncommon benign cartilaginous tumor that rarely presents in the sino-nasal region as a locally destructive, erosive lesion. Both clinically and histologically, it is a difficult diagnosis and can be confused with malignant processes such as myxoid chondrosarcoma. Histology of the tumor, especially with a small sample, can be challenging because of its heterogeneous nature showing an admixture of fibrous, myxoid, and chondroid areas. We are reporting unique cytogenetic findings in a case of chondromyxoid fibroma involving the floor of the nasal cavity with a clonal rearrangement between chromosomes 6 and 19. To our knowledge, karyotypes of 14 cases are reported in literature, with 11 cases reporting nonrandom, clonal abnormalities of chromosome 6. These results illustrate the distinctive nature of this tumor and may help identify genes involved in the pathogenesis of this tumor.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume171
Issue number2
DOIs
StatePublished - Dec 2006

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Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 6
Fibroma
Nasal Cavity
Neoplasms
Chondrosarcoma
Karyotype
Nose
Cytogenetics
Histology
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Chondromyxoid fibroma of the nasal cavity with an interstitial insertion between chromosomes 6 and 19. / Smith, Cristina A.; Magenis, R. Ellen; Himoe, Eleanor; Smith, Cheree; Mansoor, Atiya.

In: Cancer Genetics and Cytogenetics, Vol. 171, No. 2, 12.2006, p. 97-100.

Research output: Contribution to journalArticle

Smith, Cristina A. ; Magenis, R. Ellen ; Himoe, Eleanor ; Smith, Cheree ; Mansoor, Atiya. / Chondromyxoid fibroma of the nasal cavity with an interstitial insertion between chromosomes 6 and 19. In: Cancer Genetics and Cytogenetics. 2006 ; Vol. 171, No. 2. pp. 97-100.
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