Cholesterol metabolism and suicidality in smith-lemli-opitz syndrome carriers

Aleksandra Lalovic, Louise Merkens, Laura Russell, Geneviève Arsenault-Lapierre, Malgorzata J.M. Nowaczyk, Forbes D. Porter, Robert D. Steiner, Gustavo Turecki

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Objective: The authors examined the relationship between cholesterol metabolism and suicidality in carriers of Smith-Lemli-Opitz syndrome and their families. This population has a partial deficiency in 7-dehydrocholesterol reductase (DHCR7), the enzyme that catalyzes the last step in cholesterol biosynthesis. Method: Suicidal behavior, depression, misuse of alcohol and drugs, and family history of psychopathology, including attempted or completed suicide, were assessed by structured interview in 51 carriers of Smith-Lemli-Opitz syndrome and 54 matched comparison subjects. Results: There were significantly more suicide attempters and completers among the biological relatives of Smith-Lemli-Opitz syndrome carriers than comparison subjects, but family history of psychopathology did not significantly differ between the groups. More suicide attempts were reported among Smith-Lemli-Opitz syndrome carriers than among the comparison subjects. Conclusions: These results, based on a unique study design, provide additional evidence supporting the relationship between cholesterol metabolism and suicidal behavior.

Original languageEnglish (US)
Pages (from-to)2123-2125
Number of pages3
JournalAmerican Journal of Psychiatry
Volume161
Issue number11
DOIs
StatePublished - Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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