Chemical neurotoxicity

Detection and analysis in organotypic cultures of sensory and motor systems

Peter Spencer, S. M. Crain, M. B. Bornstein, E. R. Peterson, T. Van De Water

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Screening of chemical substances for human neurotoxic (and therapeutic) properties may be carried out with the aid of organotypic tissue cultures composed of foetal explants of mouse sensory and neuromuscular tissues that develop in vitro their characteristic cytoarchitectural and functional organization. Supporting this statement is a wealth of studies describing a range of specific, chemically-induced responses in organotypic neural cultures that parallel changes induced in the nervous system of humans and animals.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalFood and Chemical Toxicology
Volume24
Issue number6-7
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Chemical detection
Tissue culture
neurotoxicity
Neurology
Screening
Animals
Tissue
medicinal properties
Chemical analysis
nervous system
Nervous System
tissue culture
explants
screening
mice
animals
Therapeutics

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Chemical neurotoxicity : Detection and analysis in organotypic cultures of sensory and motor systems. / Spencer, Peter; Crain, S. M.; Bornstein, M. B.; Peterson, E. R.; Van De Water, T.

In: Food and Chemical Toxicology, Vol. 24, No. 6-7, 1986, p. 539-544.

Research output: Contribution to journalArticle

Spencer, Peter ; Crain, S. M. ; Bornstein, M. B. ; Peterson, E. R. ; Van De Water, T. / Chemical neurotoxicity : Detection and analysis in organotypic cultures of sensory and motor systems. In: Food and Chemical Toxicology. 1986 ; Vol. 24, No. 6-7. pp. 539-544.
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