Chemical Biology Toolbox for Studying Pancreatic Islet Function – A Perspective

Julia Huey, Kaya Keutler, Carsten Schultz

Research output: Contribution to journalReview articlepeer-review

Abstract

The islets of Langerhans represent one of the many complex endocrine organs in mammals. Traditionally, islet function is studied by a mixture of physiological, cell biological, and molecular biological methods. Recently, novel techniques stemming from the ever-increasing toolbox provided by chemical laboratories have been added to the repertoire. Many emerging techniques will soon be available to manipulate and monitor islet function at the single-cell level and potentially in intact model animals, as well as in isolated human islets. Here, we review the most current small-molecule-based and genetically encoded molecular tool sets available to study islet function. We provide an outlook regarding future tool developments that will impact islet research, with a special focus on the interplay between different islet cell types. The islets of Langerhans represent one of the complex endocrine organs in mammals. Huey et al. review the small-molecule-based and genetically encoded molecular toolsets available to study islet function. We provide an outlook regarding future tool development with a special focus on the interplay between different islet cell types.

Original languageEnglish (US)
Pages (from-to)1015-1031
Number of pages17
JournalCell Chemical Biology
Volume27
Issue number8
DOIs
StatePublished - Aug 20 2020

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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