Characterizing light propagation in bone for photodynamic therapy ofosteosarcoma

Vincent M. Rossi, Scott B. Gustafson, Steven L. Jacques

Research output: Contribution to journalConference article

6 Scopus citations

Abstract

This work aims at characterizing how light propagates through bone in order to efficiently guide treatment of osteosarcoma with photodynamic therapy (PDT). Optical properties of various bone tissues need to be characterized in order to have a working model of light propagation in bone. Bone tissues of particular interest include cortical bone, red and yellow marrow, cancellous bone, and bone cancers themselves. With adequate knowledge of optical properties of osseous tissues, light dosimetry can determine how best to deliver adequate light to achieve phototoxic effects within bone. An optical fiber source-collector pair is used for diffuse reflectance spectroscopic measurements in order to determine the scattering and absorption properties of bone tissues. Native absorbers of interest at visible and near-TR wavelengths include water and oxygenated and deoxygenated hemoglobin. A cylindrically symmetric Monte Carlo model is then used, incorporating these results, in order to predict and guide the delivery of light within bone in order to achieve the desired phototoxic effect in PDT.

Original languageEnglish (US)
Article number71660I
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7166
DOIs
StatePublished - Jun 22 2009
EventOptics in Bone Biology and Diagnostics - San Jose, CA, United States
Duration: Jan 24 2009Jan 24 2009

Keywords

  • Bone
  • Diffuse reflectance spectroscopy
  • Monte Carlo
  • Optical characterization
  • Osteosarcoma
  • PDT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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