Characterizing light propagation in bone for photodynamic therapy ofosteosarcoma

Vincent M. Rossi, Scott B. Gustafson, Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

This work aims at characterizing how light propagates through bone in order to efficiently guide treatment of osteosarcoma with photodynamic therapy (PDT). Optical properties of various bone tissues need to be characterized in order to have a working model of light propagation in bone. Bone tissues of particular interest include cortical bone, red and yellow marrow, cancellous bone, and bone cancers themselves. With adequate knowledge of optical properties of osseous tissues, light dosimetry can determine how best to deliver adequate light to achieve phototoxic effects within bone. An optical fiber source-collector pair is used for diffuse reflectance spectroscopic measurements in order to determine the scattering and absorption properties of bone tissues. Native absorbers of interest at visible and near-TR wavelengths include water and oxygenated and deoxygenated hemoglobin. A cylindrically symmetric Monte Carlo model is then used, incorporating these results, in order to predict and guide the delivery of light within bone in order to achieve the desired phototoxic effect in PDT.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7166
DOIs
StatePublished - 2009
EventOptics in Bone Biology and Diagnostics - San Jose, CA, United States
Duration: Jan 24 2009Jan 24 2009

Other

OtherOptics in Bone Biology and Diagnostics
CountryUnited States
CitySan Jose, CA
Period1/24/091/24/09

Fingerprint

Photodynamic Therapy
Photodynamic therapy
Light propagation
Bone
bones
therapy
Propagation
propagation
bone marrow
Tissue
Optical Properties
optical properties
Optical properties
hemoglobin
Hemoglobin
accumulators
dosimeters
Absorber
absorbers
delivery

Keywords

  • Bone
  • Diffuse reflectance spectroscopy
  • Monte Carlo
  • Optical characterization
  • Osteosarcoma
  • PDT

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Rossi, V. M., Gustafson, S. B., & Jacques, S. (2009). Characterizing light propagation in bone for photodynamic therapy ofosteosarcoma. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7166). [71660I] https://doi.org/10.1117/12.809711

Characterizing light propagation in bone for photodynamic therapy ofosteosarcoma. / Rossi, Vincent M.; Gustafson, Scott B.; Jacques, Steven.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7166 2009. 71660I.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rossi, VM, Gustafson, SB & Jacques, S 2009, Characterizing light propagation in bone for photodynamic therapy ofosteosarcoma. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7166, 71660I, Optics in Bone Biology and Diagnostics, San Jose, CA, United States, 1/24/09. https://doi.org/10.1117/12.809711
Rossi VM, Gustafson SB, Jacques S. Characterizing light propagation in bone for photodynamic therapy ofosteosarcoma. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7166. 2009. 71660I https://doi.org/10.1117/12.809711
Rossi, Vincent M. ; Gustafson, Scott B. ; Jacques, Steven. / Characterizing light propagation in bone for photodynamic therapy ofosteosarcoma. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7166 2009.
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