Changes in tumor immunity during therapy determined by leukocyte adherence inhibition and dermal testing

R. M. Vetto, D. R. Burger, Arthur Vandenbark, P. E. Finke

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Leukocyte adherence inhibition (LAI) is an easily carried out in vitro test for tumor reactivity which is based on the prevention of adherence of leukocytes incubated with antigen to which the donor is immune. In this study a comparison is made with dermal response to tumor antigen. A total of 234 patients were tested, 74 of whom had melanoma, 111 of whom had squamous cell carcinoma of the head and neck, 18 of whom had neuroblastoma and 31 of whom had other tumors. Forty-two persons without tumors acted as controls for the LAI test. A high degree of correlation was found between LAI and dermal response. Furthermore, LAI exhibited marked tumor specificity and showed a ten-fold greater sensitivity than dermal response. LAI may be used to monitor serial changes in tumor reactivity in cancer patients.

Original languageEnglish (US)
Pages (from-to)1034-1039
Number of pages6
JournalCancer
Volume41
Issue number3
StatePublished - 1978

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Immunity
Leukocytes
Skin
Neoplasms
Leukocyte Adherence Inhibition Test
Therapeutics
Neoplasm Antigens
Neuroblastoma
Melanoma
Tissue Donors
Antigens

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Changes in tumor immunity during therapy determined by leukocyte adherence inhibition and dermal testing. / Vetto, R. M.; Burger, D. R.; Vandenbark, Arthur; Finke, P. E.

In: Cancer, Vol. 41, No. 3, 1978, p. 1034-1039.

Research output: Contribution to journalArticle

Vetto, R. M. ; Burger, D. R. ; Vandenbark, Arthur ; Finke, P. E. / Changes in tumor immunity during therapy determined by leukocyte adherence inhibition and dermal testing. In: Cancer. 1978 ; Vol. 41, No. 3. pp. 1034-1039.
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